PMID: 3747462Aug 1, 1986Paper

Viscoelastic properties of microvessels in rat spinotrapezius muscle

Journal of Biomechanical Engineering
T C Skalak, G W Schmid-Schönbein

Abstract

In order to establish a quantitative model of blood flow in skeletal muscle, the mechanical properties of the blood vessels need to be measured. We present measurements of the viscoelastic properties of arterioles, venules, and capillaries in exteriorized rat spinotrapezius muscle. Muscles were perfused with an inert silicone polymer and a uniform static pressure was established by occlusion of the venous outflow. Vessel diameters were then measured as a function of the static pressure. This study provides the first measurements of the viscoelastic properties of microvessels in skeletal muscle in situ. Over a pressure range of 20-200 mmHg, the transverse arterioles are the most distensible vessels, while the arcade venules are the stiffest. In response to a step change in pressure, all vessels show an initial elastic deformation, followed by a nonlinear creep. Based on the experimental results for different pressure histories a constitutive equation relating vessel diameter to the local transmural pressure is proposed. Diameter changes are expressed in the form of a diameter strain, analogous to a Green's strain, and are related to the local transmural pressure using a standard linear solid model. This model has only three empi...Continue Reading

Citations

May 1, 1996·Journal of Biomechanics·M AbovskyE Nevo
Apr 20, 2001·Journal of Biomechanics·C C van DonkelaarM R Drost
Sep 4, 1998·Journal of Biomechanics·W J VankanA Huson
Apr 7, 1999·International Journal of Radiation Oncology, Biology, Physics·M F MilosevicR P Hill
Jan 24, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Thom P SantisakultarmChris B Schaffer
Feb 14, 2008·Particle and Fibre Toxicology·Timothy R NurkiewiczVincent Castranova
May 1, 1996·Journal of Biomechanical Engineering·S Lee, G W Schmid-Schönbein
Nov 1, 1986·Microvascular Research·T C Skalak, G W Schmid-Schönbein
Nov 10, 2001·Annual Review of Biomedical Engineering·G W Schmid-Schönbein
May 11, 2016·Biotechnology Progress·William G PittAlex K Hunter
May 6, 2005·The International Journal of Lower Extremity Wounds·David Schley
Sep 1, 1995·Pflügers Archiv : European journal of physiology·J BosmanD W Slaaf
Feb 1, 1987·Hypertension·G W Schmid-SchönbeinP C Chen
Dec 22, 1999·The American Journal of Physiology·G S KassabY C Fung
Dec 22, 2020·Microvascular Research·Krianthan GovenderPedro Cabrales
Sep 9, 2021·Journal of Biomechanical Engineering·Gabrielle L Clark-PattersonKristin S Miller

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