Viscoelastic properties of mineralized alginate hydrogel beads.

Journal of Materials Science. Materials in Medicine
Magnus O OlderøyPawel Sikorski

Abstract

Alginate hydrogels have applications in biomedicine, ranging from delivery of cells and growth factors to wound management aids. However, they are mechanically soft and have shown little potential for the use in bone tissue engineering. Here, the viscoelastic properties of alginate hydrogel beads mineralized with calcium phosphate, both by a counter-diffusion (CD) and an enzymatic approach, are characterized by a micro-manipulation technique and mathematical modeling. Fabricated hydrogel materials have low mineral content (below 3 % of the total hydrogel mass, which corresponds to mineral content of up to 60 % of the dry mass) and low dry mass content (<5 %). For all samples compression and hold (relaxation after compression) data was collected and analyzed. The apparent Young's modulus of the mineralized beads was estimated by the Hertz model (compression data) and was shown to increase up to threefold upon mineralization. The enzymatically mineralized beads showed higher apparent Young's modulus compared to the ones mineralized by CD, even though the mineral content of the former was lower. Full compression-relaxation force-time profiles were analyzed using viscoelastic model. From this analysis, infinite and instantaneous Yo...Continue Reading

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Citations

Oct 27, 2015·Biomaterials·Andrea M UnserYubing Xie
Jul 3, 2018·Journal of Biomaterials Science. Polymer Edition·Anil Parameswaran-ThankamAnindya Ghosh
Mar 26, 2013·Materials·Jinchen Sun, Huaping Tan
Feb 17, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Guangsheng DuXun Sun
Jan 14, 2021·Carbohydrate Polymers·Ioanna ZafeiriIan Norton

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