Viscoelastic properties of skin in Mov-13 and Tsk mice

Journal of Biomechanics
Z Del PreteP Grigg

Abstract

Viscoelastic properties of skin samples were measured in three types of mice (tight skin, Tsk, control and Mov-13), that are known to differ with regard to content of type I collagen. The experimental design used uniaxial stretching and measured the creep response and the complex compliance. The creep response was measured directly. The complex compliance was determined using a Wiener-Volterra constitutive model for each sample. The models were calculated from data obtained by applying a stress input having a pseudo-Gaussian waveform and measuring the strain response. The storage compliance of Mov-13 and control skin were similar and were greater than Tsk (p<0.001). The loss compliance of each group was significantly different (p<0.001) from each other group; Tsk had the lowest and control had the highest loss compliance. The phase angle of the Mov-13 and Tsk were similar and were less than the controls (p<0.001). The creep response was fit with a linear viscoelastic model. None of the parameters in the creep model differed between groups. The results indicate that gene-targeted and mutant animals have soft tissue mechanical phenotypes that differ in complex ways. Caution should be exercised when using such animals as models to...Continue Reading

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Citations

Jan 28, 2006·American Journal of Respiratory Cell and Molecular Biology·Satoru ItoBélâ Suki
Nov 22, 2013·Biochemistry Research International·Jayanthi ManneSergio A Jimenez
Aug 4, 2015·Journal of Biomechanics·A S Caro-BretelleF Bretelle
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