Viscoelastic second normal stress difference dominated multiple-stream particle focusing in microfluidic channels

Applied Physics Letters
Haidong FengBruce Kent Gale

Abstract

Particle focusing in viscoelastic fluid flow is a promising approach for inducing particle separations in microfluidic devices. The results from theoretical studies indicated that multiple stream particle focusing can be realized with a large magnitude of the elastic second normal stress difference (N2). For dilute polymer solutions, theoretical and experimental studies show that the magnitude of N2 is never large, no matter how large the polymer molecular weight nor how high the shear rate. However, for concentrated entangled polymer solutions, the magnitude of N2 becomes large at high shear rates. Therefore, in order to test the hypothesis that N2 can be used to induce multiple particle stream focusing behavior, we perform the systematic study of the effects of increasing carrier fluid polymer concentrations in a microchannel containing fluorescent particles. In a dilute polymer solution, multiple particle stream focusing is not observed, even at high shear rates and large dimensionless Weissenberg number values (Wi ≈ 30) at which the elastic first normal stress difference (N1) and the viscosity shear-thinning should be very large, while in a concentrated entangled polymer solution, we observe that particle streams focused up...Continue Reading

References

Aug 7, 2007·Physical Review Letters·A M LeshanskyU Dinnar
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dino Di CarloMehmet Toner
Feb 16, 2008·Analytical Chemistry·Dino Di CarloMehmet Toner
Oct 1, 2009·Lab on a Chip·Sathyakumar S KuntaegowdanahalliIan Papautsky
Oct 14, 2009·Lab on a Chip·Dino Di Carlo
Apr 9, 2010·Analytical Chemistry·John OakeyMehmet Toner
Mar 29, 2012·Physics of Fluids·Joseph M Martel, Mehmet Toner
Nov 20, 2013·Scientific Reports·Doo Jin LeeYoung Seok Song
Jun 11, 2014·Lab on a Chip·Hamed AminiDino Di Carlo
Apr 5, 2017·Analytical Chemistry·Sei Hyun YangYoung Seok Song
Jan 18, 2018·Lab on a Chip·Dan YuanWeihua Li

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