PMID: 16502660Mar 1, 2006Paper

Viscoelastic testing methodologies for tissue engineered blood vessels

Journal of Biomechanical Engineering
Joseph D BerglundAthanassios Sambanis

Abstract

In order to function in vivo, tissue engineered blood vessels (TEBVs) must encumber pulsatile blood flow and withstand hemodynamic pressures for long periods of time. To date TEBV mechanical assessment has typically relied on single time point burst and/or uniaxial tensile testing to gauge the strengths of the constructs. This study extends this analysis to include creep and stepwise stress relaxation viscoelastic testing methodologies. TEBV models exhibiting diverse mechanical behaviors as a result of different architectures ranging from reconstituted collagen gels to hybrid constructs reinforced with either untreated or glutaraldhyde-crosslinked collagen supports were evaluated after 8 and 23 days of in vitro culturing. Data were modeled using three and four-parameter linear viscoelastic mathematical representations and compared to porcine carotid arteries. While glutaraldhyde-treated hybrid TEBVs exhibited the largest overall strengths and toughness, uncrosslinked hybrid samples exhibited time-dependent behaviors most similar to native arteries. These findings emphasize the importance of viscoelastic characterization when evaluating the mechanical performance of TEBVs. Limits of testing methods and modeling systems are prese...Continue Reading

References

Mar 1, 1974·Journal of Biomechanics·Y Lanir, Y C Fung
Jan 23, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N L'HeureuxF A Auger
Apr 16, 1999·Science·L E NiklasonR Langer
Jun 28, 2000·Annals of Biomedical Engineering·D SeliktarR M Nerem
Aug 3, 2000·Journal of Biomechanical Engineering·T S GirtonR T Tranquillo
Jun 5, 2002·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·Alok TiwariGeorge Hamilton
Jul 3, 2002·Circulation·Kalpana LakhaniPaul Hardiman
Jan 16, 2003·Biomaterials·Joseph D BerglundAthanassios Sambanis
May 6, 2003·Annual Review of Biomedical Engineering·Raymond P Vito, Stacey A Dixon
Aug 22, 2003·Journal of Biomechanical Engineering·Christian A J Schulze-BauerGerhard A Holzapfel
Oct 17, 2003·American Journal of Physiology. Heart and Circulatory Physiology·X LuG S Kassab

❮ Previous
Next ❯

Citations

Oct 27, 2007·Tissue Engineering·Jan P StegemannShaneen L Rowe
Dec 3, 2008·Journal of Biomechanical Engineering·W ZhangG S Kassab
May 20, 2009·Journal of Biomechanical Engineering·Shaneen L Rowe, Jan P Stegemann
Apr 19, 2008·Journal of Biomaterials Science. Polymer Edition·Leah SofferGary Leisk
Mar 19, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Véronique LaterreurLucie Germain
Aug 20, 2011·Connective Tissue Research·Miglena Kirilova
Oct 4, 2012·Biomaterials·Jean-Michel BourgetLucie Germain
May 22, 2007·Biomaterials·Wei ZhangGhassan S Kassab
Feb 11, 2011·Journal of Biomedical Materials Research. Part a·Krishna MadhavanWei Tan
Apr 7, 2012·IEEE Transactions on Bio-medical Engineering·Jing Jin ShenJavad Dargahi
Jul 31, 2012·International Journal of Biomaterials·Sébastien MegheziDiego Mantovani
Feb 23, 2017·Annals of Biomedical Engineering·N BonoGianfranco Beniamino Fiore
Dec 14, 2016·Cardiovascular Engineering and Technology·Hanna E BurtonDaniel M Espino
Aug 1, 2009·Asian Cardiovascular & Thoracic Annals·Uwe Klima, Theo Kofidis
Apr 12, 2017·Journal of Materials Science. Materials in Medicine·Chiara MarcolinSilvia Faré
Nov 21, 2019·Regenerative Medicine·Tatiane Eufrásio-da-SilvaBruce P Murphy
Feb 11, 2018·Journal of the Mechanical Behavior of Biomedical Materials·Dawit G SeifuDiego Mantovani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.