Viscoelasticity of spinal cord and meningeal tissues

Acta Biomaterialia
Nicole L RamoChristian M Puttlitz

Abstract

Compared to the outer dura mater, the mechanical behavior of spinal pia and arachnoid meningeal layers has received very little attention in the literature. This is despite experimental evidence of their importance with respect to the overall spinal cord stiffness and recovery following compression. Accordingly, inclusion of the mechanical contribution of the pia and arachnoid maters would improve the predictive accuracy of finite element models of the spine, especially in the distribution of stresses and strain through the cord's cross-section. However, to-date, only linearly elastic moduli for what has been previously identified as spinal pia mater is available in the literature. This study is the first to quantitatively compare the viscoelastic behavior of isolated spinal pia-arachnoid-complex, neural tissue of the spinal cord parenchyma, and intact construct of the two. The results show that while it only makes up 5.5% of the overall cross-sectional area, the thin membranes of the innermost meninges significantly affect both the elastic and viscous response of the intact construct. Without the contribution of the pia and arachnoid maters, the spinal cord has very little inherent stiffness and experiences significant relaxat...Continue Reading

Citations

Mar 6, 2019·Journal of Biomechanical Engineering·Nicole L RamoChristian Puttlitz
Dec 22, 2019·Bioengineering·Wenqiang Liu, Zhijie Wang
Jan 5, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Patrice SudresYvan Petit
Mar 2, 2021·Curēus·Bruno BordoniLuigi Pianese
Nov 14, 2020·Fluids and Barriers of the CNS·Gabryel Conley NatividadBryn A Martin
Jun 18, 2021·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Majid SiamiMousa Rezaee
Aug 31, 2021·Frontiers in Bioengineering and Biotechnology·Aleksander RycmanDuane S Cronin
Aug 21, 2021·Journal of Neurosurgery. Spine·Amro Al-HabibAbdulrazag Ajlan
Jan 9, 2022·International Journal for Numerical Methods in Biomedical Engineering·Aleksander RycmanDuane S Cronin

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