Viscum album L. preparation Isorel modifies the immune response in normal and in tumour-bearing mice

Anti-cancer Drugs
M JurinD Kissel

Abstract

The Viscum album (mistletoe) preparation Isorel is able to destroy tumour cells and to modify immune reactivity against a particular antigen in normal and in tumour-bearing animals. CBA/HZgr mice and methylcholanthrene-induced fibrosarcoma were used in these studies. A single dose of Isorel M (140 mg/kg or 1400 mg/kg body weight) significantly increased the number of plaque forming cells if applied at the time of injection of sheep red blood cells or 1 day earlier. The application of Isorel 1 day after sheep red blood cells did not modify the number of plaque forming cells in comparison to the controls. The higher the dose of Isorel the stronger is the immune response to sheep red blood cells. Furthermore, one dose of Isorel (140 mg/kg body weight) restored the suppressed immune response of fibrosarcoma-bearing mice to a significant extent. Besides modification of the humoral immune response, the survival time of C57BI/GoZgr male skin grafts on syngeneic female recipients was significantly shorter if Isorel was applied at a particular time after grafting. However, according to plaque forming cell numbers, a prolonged application of Isorel was significantly immunosuppressive in normal mice and particularly in tumour-bearing mice...Continue Reading

Citations

Mar 31, 2001·Cancer Biotherapy & Radiopharmaceuticals·N ZarkovicS Mang
Aug 30, 2011·BMC Complementary and Alternative Medicine·Gunver S KienleHelmut Kiene
Jun 10, 2017·Experimental and Therapeutic Medicine·Leoni Villano BonaminSilvia Waisse

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