Visibility of microcalcification clusters and masses in breast tomosynthesis image volumes and digital mammography: a 4AFC human observer study

Medical Physics
P TimbergMark Ruschin

Abstract

To investigate the visibility of simulated lesions in digital breast tomosynthesis (BT) image volumes compared with 2D digital mammography (DM). Simulated lesions (masses and microcalcifications) were added to images of the same women acquired on a DM system (Mammomat Novation, Siemens) and a BT prototype. The same beam quality was used for the DM and BT acquisitions. The total absorbed dose resulting from a 25-projection BT acquisition and reconstruction (BT(25)) was approximately twice that of a single DM view. By excluding every other projection image from the reconstruction (BT(13)), approximately the same dose as in DM was effected. Simulated microcalcifications were digitally added with varying contrast to the DM and BT images. Simulated masses with 8 mm diameter were also added to BT images. A series of 4-alternative forced choice (4AFC) human observer experiments were conducted. Four medical physicists participated in all experiments, each consisting of 60 trials per experimental condition. The observers interpreted the BT image volumes in cine-mode at a fixed image sequence speed. The required threshold contrast (S(t)) to achieve a detectability index (d') of 2.5 (i.e., 92.5% correct decisions) was determined. The S(t)...Continue Reading

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Citations

Aug 5, 2014·Medical Physics·Eman ShaheenChantal Van Ongeval
Mar 8, 2013·Clinical Radiology·M AlakhrasP C Brennan
Nov 4, 2015·Journal de gynécologie, obstétrique et biologie de la reproduction·F Chamming'sE Chéreau
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Apr 5, 2017·Journal of Medical Radiation Sciences·Suneeta MallClaudia Mello-Thoms
Apr 12, 2018·Physics in Medicine and Biology·Premkumar ElangovanKevin Wells
Aug 13, 2014·World Journal of Clinical Oncology·Stephane ZervoudisGeorge Tsakiris
Apr 29, 2018·Medical Physics·Alexandre BaFrançois O Bochud
Jan 24, 2017·AJR. American Journal of Roentgenology·Judy R JamesBhavika K Patel
Feb 6, 2020·Medical Physics·Gihun KimJongduk Baek
Apr 23, 2016·Clinical Obstetrics and Gynecology·Tanya W Moseley
Dec 9, 2016·Journal of Applied Clinical Medical Physics·Robert LorentssonMagnus Båth
Apr 25, 2015·Physics in Medicine and Biology·Lesley CockmartinHilde Bosmans
May 25, 2021·Journal of Medical Imaging·Joana BoitaIoannis Sechopoulos

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