Visible and near-infrared spectra collected from the thumbs of patients with chronic fatigue syndrome for diagnosis

Clinica Chimica Acta; International Journal of Clinical Chemistry
Akikazu SakudoKazuyoshi Ikuta

Abstract

Currently, diagnosis of chronic fatigue syndrome (CFS) is based on clinical symptoms and therefore relies on the experience and skill of the doctors. Here, we have examined the possible diagnosis of CFS based on spectral information and chemometrics analysis, such as principal component analysis (PCA) and soft modeling of class analogy (SIMCA). Visible and near-infrared (Vis-NIR) spectroscopy was used to examine possible changes in the region of 600-1100 nm in thumbs and assessed. The Vis-NIR spectra of thumbs from 57 CFS patients and 74 healthy volunteers were subjected to PCA and SIMCA to develop multivariate models to discriminate between CFS patients and healthy individuals. The model was further assessed by the prediction of 120 determinations (60 in the healthy group and 60 in the CFS patient group). The PCA model predicted a discrimination of the masked samples; specifically the SIMCA model correctly predicted 51 of 60 (83.3%) healthy volunteers and 42 of 60 (70%) CFS patients. Despite the relatively small number of subjects involved in this trial, who were exclusively Japanese, our results imply that Vis-NIR spectroscopy of the thumb combined with chemometrics analysis may provide a valuable tool for diagnosing CFS.

References

Jun 23, 2000·The Netherlands Journal of Medicine·P M SoetekouwJ W van der Meer
Feb 19, 2003·Clinical Science·Kevin K McCullyBenjamin H Natelson
Jan 18, 2006·Biochemical and Biophysical Research Communications·Akikazu SakudoKazuyoshi Ikuta
May 30, 2006·Biochemical and Biophysical Research Communications·Akikazu SakudoKazuyoshi Ikuta
Jan 20, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Akikazu SakudoKazuyoshi Ikuta
Mar 3, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Akikazu SakudoKazuyoshi Ikuta
Jun 3, 2009·Cleveland Clinic Journal of Medicine·William S Wilke
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Jul 23, 2011·Journal of Internal Medicine·B M CarruthersS Stevens

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Citations

Feb 16, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Akikazu Sakudo
Jun 29, 2015·Computers in Biology and Medicine·Yunhua ChenYanjun Zeng
Sep 11, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Akikazu SakudoKazuyoshi Ikuta

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