Visible-Light-Driven Copper-Catalyzed C(sp3 )-O Cross-Coupling of Benzylic Radicals with Phenols

Organic Letters
Xiao-Ye YuJia-Rong Chen

Abstract

A visible-light-driven, copper-catalyzed C(sp3)-O coupling of benzylic radicals with phenols is described for the first time. This operationally simple and robust process features mild conditions, broad scope, and high functional-group tolerance, enabling the construction of a diverse range of cyanoalkylated aryl ethers (33 examples). Key to this protocol is the dual role of copper salt that acts not only as a photosensitizer but also as a cross-coupling catalyst.

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Citations

Sep 24, 2020·Organic & Biomolecular Chemistry·Chengkou LiuKai Guo
Sep 24, 2020·Chemical Communications : Chem Comm·Hai-Yan SuFeng-Ling Qing
Oct 1, 2020·Chemical Communications : Chem Comm·Shuai LiuYannick Landais

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