Visible-Light-Induced Tandem Radical Addition-Cyclization of Alkenyl Aldehydes Leading to Indanones and Related Compounds

Organic Letters
Danyang LuGangguo Zhu

Abstract

Herein we describe a novel, visible light-induced tandem radical addition-cyclization of alkenyl aldehydes with α-bromocarbonyl compounds. A set of cyclic ketones, including indanones, cyclopentenones, 3,4-dihydronaphthalen-1(2H)-ones, and chroman-4-ones, are synthesized at room temperature with high efficiency and good functional group compatibility. It represents the first report on the catalytic 1,2-acylalkylation of unactivated alkenes.

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Citations

Jun 29, 2018·Chemical Communications : Chem Comm·Weiwei JinGangguo Zhu
Jul 19, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Yating ZhaoWujiong Xia
Jul 7, 2018·Chemistry, an Asian Journal·Xuan-Hui OuyangJin-Heng Li

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