Visible-Light-Mediated Synthesis of Amides from Aldehydes and Amines via in Situ Acid Chloride Formation

The Journal of Organic Chemistry
Naeem Iqbal, Eun Jin Cho

Abstract

An efficient visible-light photocatalysis-based one-pot amide synthesis method was developed; visible-light irradiation of a mixture of an aldehyde, tert-butyl hydrogen peroxide, and N-chlorosuccinimide using a Ru(bpy)3Cl2 photocatalyst afforded an acid chloride, which subsequently reacted with amine to yield the corresponding amide. The reaction was used to synthesize moclobemide and a D3 receptor intermediate.

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Citations

May 27, 2016·The Journal of Organic Chemistry·Giorgos N Papadopoulos, Christoforos G Kokotos
Aug 26, 2017·Chemical Communications : Chem Comm·Irit CohenAlex M Szpilman
Jan 11, 2020·Chemistry : a European Journal·Sk Sheriff ShahN D Pradeep Singh
Sep 21, 2017·Angewandte Chemie·Satobhisha MukherjeeFrank Glorius
Apr 18, 2017·European Journal of Organic Chemistry·Luca Capaldo, Davide Ravelli
Jan 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberto SoleValentina Beghetto
Oct 20, 2020·The Journal of Organic Chemistry·Rolando CannalireMariateresa Giustiniano
Jul 15, 2020·The Journal of Organic Chemistry·Silvia GaspaLidia De Luca
Feb 24, 2021·Angewandte Chemie·Abhaya K MishraAlex M Szpilman
Mar 28, 2021·Chemistry : a European Journal·Nikolaos F NikitasChristoforos G Kokotos
Jun 17, 2020·The Journal of Organic Chemistry·Jyoti NandiNicholas E Leadbeater
Sep 30, 2021·Chemical Reviews·Natalie Holmberg-Douglas, David A Nicewicz

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