Vision-Related Quality-of-Life Outcomes in the Mycotic Ulcer Treatment Trial I: A Randomized Clinical Trial

JAMA Ophthalmology
Jennifer Rose-NussbaumerMycotic Ulcer Treatment Trial I Group

Abstract

Given the limitations in health care resources, quality-of-life measures for interventions have gained importance. To determine whether vision-related quality-of-life outcomes were different between the natamycin and voriconazole treatment arms in the Mycotic Ulcer Treatment Trial I, as measured by an Indian Vision Function Questionnaire. Secondary analysis (performed October 11-25, 2014) of a double-masked, multicenter, randomized, active comparator-controlled, clinical trial at multiple locations of the Aravind Eye Care System in South India that enrolled patients with culture- or smear-positive filamentous fungal corneal ulcers who had a baseline visual acuity of 20/40 to 20/400 (logMAR of 0.3-1.3). Study participants were randomly assigned to topical voriconazole, 1%, or topical natamycin, 5%. Subscale score on the Indian Vision Function Questionnaire from each of the 4 subscales (mobility, activity limitation, psychosocial impact, and visual function) at 3 months. A total of 323 patients were enrolled in the trial, and 292 (90.4%) completed the Indian Vision Function Questionnaire at 3 months. The majority of study participants had subscale scores consistent with excellent function. After adjusting for baseline visual acui...Continue Reading

Associated Clinical Trials

Oct 16, 2009·Thomas M. Lietman, Thomas M. Lietman

Citations

Jan 8, 2020·BMJ Open Ophthalmology·Simon ArungaMatthew Burton
Jul 6, 2019·Cornea·Dena BallouzMaria A Woodward
Nov 5, 2015·The British Journal of Ophthalmology·Jennifer Rose-NussbaumerUNKNOWN Mycotic Ulcer Treatment Trial Group
Mar 1, 2020·Lasers in Medical Science·Yingyu LiWei Wang
Jun 3, 2020·Cornea·Megan M TuohyMaria A Woodward
Feb 14, 2018·American Journal of Ophthalmology·Kathryn J RayUNKNOWN Mycotic Ulcer Treatment Trial Group

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