Visit-To-Visit Blood Pressure Variability and the Risk of Dementia in Older People

Journal of Alzheimer's Disease : JAD
Tessa van MiddelaarEdo Richard

Abstract

High visit-to-visit variability (VVV) in blood pressure (BP) is associated with cerebrovascular lesions on neuroimaging. Our primary objective was to investigate whether VVV is associated with incident all-cause dementia. As a secondary objective, we studied the association of VVV with cognitive decline and cardiovascular disease (CVD). We included community-dwelling people (age 70-78 year) from the 'Prevention of Dementia by Intensive Vascular Care' (preDIVA) trial with three to five 2-yearly BP measurements during 6-8 years follow-up. VVV was defined using coefficient of variation (CV; SD/mean×100). Cognitive decline was assessed using the Mini-Mental State Examination (MMSE). Incident CVD was defined as myocardial infarction or stroke. We used a Cox proportional hazard regression and mixed-effects model adjusted for sociodemographic factors and cardiovascular risk factors. In 2,305 participants (aged 74.2±2.5), mean systolic BP over all available visits was 150.1 mmHg (SD 13.6), yielding a CV of 9.0. After 6.4 years (SD 0.8) follow-up, 110 (4.8%) participants developed dementia and 140 (6.1%) CVD. Higher VVV was not associated with increased risk of dementia (hazard ratio [HR] 1.00 per point CV increase; 95% confidence inter...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Jul 22, 2005·Lancet Neurology·Chengxuan QiuLaura Fratiglioni
Jul 1, 2009·Hypertension·Robert StewartLenore J Launer
Oct 9, 2009·Alzheimer Disease and Associated Disorders·Edo RichardWillem A Van Gool
May 12, 2010·Archives of Neurology·Adam M BrickmanRichard Mayeux
Jul 29, 2011·Neurology·Alastair John Stewart WebbPeter Malcolm Rothwell
Nov 29, 2012·Journal of Hypertension·Rosalinde K E PoortvlietJeanet W Blom
Feb 7, 2013·BMC Medical Research Methodology·Sally R Hinchliffe, Paul C Lambert
Feb 13, 2013·Nature Reviews. Cardiology·Gianfranco ParatiGrzegorz Bilo
Aug 21, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Annick AlpérovitchChristophe Tzourio
May 17, 2017·Journal of Hypertension·Tessa van MiddelaarWillem A van Gool
Jun 10, 2017·Journal of Alzheimer's Disease : JAD·Michiaki NagaiAkane Tsuchiya

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Citations

Apr 26, 2018·The Journal of Clinical Hypertension·Simona LattanziMauro Silvestrini
Nov 2, 2018·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kei Kamide, Mai Kabayama
Sep 24, 2019·Hypertension·Rianne A A de HeusUNKNOWN NILVAD Study Group
Jul 28, 2020·American Journal of Hypertension·Yuan MaChristophe Tzourio
Apr 13, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Laure RouchUNKNOWN MAPT/DSA Group
May 26, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Hao HuJin-Tai Yu
May 28, 2019·Journal of the American Medical Directors Association·Tessa van MiddelaarJan-Willem van Dalen
Sep 20, 2021·Experimental Gerontology·Jane A H Masoli, João Delgado

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