Visna-maedi virus induces interleukin-8 in sheep alveolar macrophages through a tyrosine-kinase signaling pathway

American Journal of Respiratory Cell and Molecular Biology
I LegasteloisG Cordier

Abstract

The mechanisms leading to the severe lung damage seen in some sheep naturally infected with the visna-maedi virus, and to pulmonary lesions in other lentiviral diseases, appear to involve the recruitment of large numbers of uninfected inflammatory cells. Only a few alveolar macrophages from experimentally infected lambs express virus, but high levels of interleukin (IL)-8 mRNA are present in the macrophage population. In vitro infection with visna-maedi virus at low multiplicity of alveolar macrophages from uninfected sheep also strongly induced the expression of IL-8 mRNA and the accumulation of IL-8 in the extracellular medium. An initial peak of IL-8 mRNA expression at 3 or 6 h after infection was followed by a fall, then a more persistent expression lasting at least 48 h after infection. The early peak was accompanied by expression of mRNA for IL-1beta, and a possible rise in tumor necrosis factor alpha (TNFalpha) mRNA, although this was frequently elevated in uninfected ovine alveolar macrophages. Interestingly, these events occurred identically in cells treated with non-infectious heat-treated virus, suggesting that interaction between viral components and cellular membrane receptors could suffice for both early and late ...Continue Reading

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Citations

Apr 16, 2013·Comparative Immunology, Microbiology and Infectious Diseases·Amaia LarruskainBegoña M Jugo
Mar 15, 2001·Comparative Immunology, Microbiology and Infectious Diseases·D SalvatoriA Vita
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Oct 10, 2002·The Veterinary Record·H YilmazK L Morgan
Apr 25, 2013·Viruses·Hugo RamírezHumberto A Martínez

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