Visnagin attenuates acute pancreatitis via Nrf2/NFκB pathway and abrogates associated multiple organ dysfunction

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Lakshmi Priya PasariChandraiah Godugu

Abstract

Acute pancreatitis (AP) is an exocrine dysfunction of the pancreas where oxidative stress and inflammatory cytokines play a key role in induction and progression of the disease. Studies have demonstrated that antioxidant phytochemicals have been effective in improving pancreatitis condition, but there are no clinically approved drugs till date. Our study aims to assess the preventive activity of visnagin, a novel phytochemical isolated from Ammi visnaga against cerulein induced AP. Male Swiss albino mice were divided into six groups (n = 6, each group) comprising of normal control, cerulein control, seven day pre-treatment with visnagin at three dose levels; visnagin low dose (10 mg/kg), visnagin mid dose (30 mg/kg), visnagin high dose (60 mg/kg) and visnagin control (60 mg/kg). AP was induced by six injections of cerulein (50 μg/kg, i.p.) on the 7th day and the animals were sacrificed after 6 h of last cerulein dose. Various markers of pancreatic function, oxidative stress and inflammation were assessed. Visnagin was found to be effective in reducing plasma amylase and lipase levels, reduced cerulein induced oxidative stress. Visnagin dose dependently decreased the expression of IL-1β, IL-6, TNF-α and IL-17. It attenuated the ...Continue Reading

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Citations

Jun 13, 2019·BioFactors·Chandra S PeddakkulappagariChandraiah Godugu
Jul 16, 2020·International Journal of Immunopathology and Pharmacology·Yang TanChuan-Yun Qian
May 7, 2020·Advanced Pharmaceutical Bulletin·Kamal AbdolmohammadiMohammad Hossein Nicknam
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Oct 30, 2020·Drug Delivery·Xue JiangLongfa Kou
Nov 18, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Walaa Yehia AbdelzaherMaha Yehia Kamel

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