PMID: 11310708Apr 20, 2001Paper

Visual acuities after levodopa administration in amblyopia

Journal of Pediatric Ophthalmology and Strabismus
Kanwar MohanA Sharma

Abstract

To investigate the effect of the augmentation of levodopa with part-time and full-time occlusion on visual acuity and to determine its late results in amblyopia. Seventy-two patients with amblyopia were prospectively studied and randomly distributed into groups A, B, and C consisting of 24 patients each. Group A patients received levodopa alone, group B received levodopa and part-time (3 hours/day) occlusion, and group C received levodopa and full-time (during all waking hours) occlusion of the dominant eye. Levodopa 0.50 mg/kg body weight, with a 25% fixed dose combination of carbidopa, was administered orally three times a day for 7 weeks. Snellen visual acuity and its logMAR equivalent were recorded before treatment, at weeks 1, 3, 5, and 7 after starting treatment, and every 6 weeks for 1 year after the completion of treatment. Fifty-three (74%) of the 72 patients had an improvement in visual acuity after treatment. Forty-four of the 53 patients with improved visual acuities completed 1-year post-treatment follow-up. Twenty-three (52%) of the 44 patients had a regression in visual acuity. The augmentation of levodopa with part-time or full-time occlusion does not enhance the recovery of vision in amblyopia. Improved visual ...Continue Reading

Citations

Jun 16, 2005·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Antonio AlgazeGary Rogers
Mar 8, 2005·Survey of Ophthalmology·Kurt Simons
Mar 6, 2003·Neuroscience Letters·Chao-I YangHo-Ling Liu
Sep 15, 2010·Archives of Ophthalmology·Michael X RepkaUNKNOWN Pediatric Eye Disease Investigator Group
May 24, 2014·Pediatric Clinics of North America·Diana DeSantis
Mar 26, 2016·Biomedical Journal·Gail D E Maconachie, Irene Gottlob
Mar 20, 2014·Clinical & Experimental Ophthalmology·C Gail SummersMurray H Brilliant
Jan 3, 2006·American Journal of Ophthalmology·Carolyn Wu, David G Hunter
Feb 14, 2015·Ophthalmology·UNKNOWN Pediatric Eye Disease Investigator GroupDavid K Wallace

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