In 48 patients with multiple sclerosis sine-wave gratings were used to test visual sensitivity for coarse, medium, and fine detail rather than measuring visual acuity for fine detail only, as in conventional clinical tests. In 20/48 patients the test revealed a visual defect of neural origin, qualitatively different from that caused by refractive error. In 11 of these 20 patients, visual sensitivity to detail of medium coarseness was markedly degraded, even though sensitivity to both coarse and fine detail was unimpaired. In 3 of these 20 patients visual sensitivity to coarse detail was selectively degraded. These visual defects could not be detected by the Snellen test, yet the patient might experience visual problems in everyday life and also experience distorted visual perception. Possible neural bases for these visual impairments are discussed. Since 8 of the 14 patients with selective loss showed no clinical evidence of visual involvement, the test can aid the earlier diagnosis of multiple sclerosis.
Foveal versus peripheral retinal responses: a new analysis for early diagnosis of multiple sclerosis
Visual evoked potentials and positron emission tomographic mapping of regional cerebral blood flow and cerebral metabolism: can the neuronal potential generators be visualized?
Hypocomplementaemic and normocomplementaemic multiple sclerosis. Genetic determinism and association with specific HLA determinants (B18 and B7)
The effects of field size and luminance on contrast sensitivity differences between specifically reading disabled and normal children
Visual acuity is associated with performance on visual and non-visual neuropsychological tests in multiple sclerosis
A clinical and electroencephalographic study on anti-epileptic activity of clonazepam. Relationship between clinical effects of oral administration and electroencephalographic effects of intravenous administration
Assessment of contrast sensitivity of patients with macular disease using reduced contrast near visual acuity charts
Influence of the rate of contrast change on the quality of contrast sensitivity assessment: a comparison of three psychophysical methods
Pattern-sensitive epilepsy. I: A demonstration of a spatial frequency selective epileptic response to gratings
Low-contrast letter charts in early diabetic retinopathy, ocular hypertension, glaucoma, and Parkinson's disease
Impaired contrast sensitivity in diabetic patients with and without retinopathy: a new technique for rapid assessment
Effect of body temperature on visual evoked potential delay and visual perception in multiple sclerosis
The effect of temporal frequency variation on threshold contrast sensitivity deficits in optic neuritis
Contrast sensitivity in multiple sclerosis measured by Cambridge Low Contrast Gratings: a useful clinical test?
Optic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes
Acute effect of the carbon dioxide laser on the epicerebral microcirculation. Experimental study by fluorescein angiography
Contrast sensitivity in relapsing-remitting multiple sclerosis assessed by sine-wave gratings and angular frequency stimuli
Comparison of psychophysical and evoked potential methods in the detection of visual deficits in multiple sclerosis
The utility of visual evoked potentials using hemifield stimulation and several check sizes in the evaluation of suspected multiple sclerosis
Influence of multiple sclerosis, age and degree of disability, in the position of the contrast sensitivity curve peak
Subtle disturbances of vision with compressive lesions of the anterior visual pathway measured by contrast sensitivity
Alterations in the neurocytotoxicity of 5,7-dihydroxytryptamine by pharmacologic agents in adult and developing rats
Biochemical, behavioral, and pharmacologic studies of the effects of dihydroxytryptamines in the rodent brain
The pointillism method for creating stimuli suitable for use in computer-based visual contrast sensitivity testing
Self-reported visual dysfunction in multiple sclerosis: new data from the VFQ-25 and development of an MS-specific vision questionnaire
The paracentral visual field in multiple sclerosis: evidence for a deficit in interneuronal spatial summation?
Self-reported visual dysfunction in multiple sclerosis: results from the 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25)
Validity of low-contrast letter acuity as a visual performance outcome measure for multiple sclerosis
The risk of multiple sclerosis developing in patients with isolated idiopathic optic neuritis in Brazil
New low-contrast vision charts: reliability and test characteristics in patients with multiple sclerosis
Contrast sensitivity in evaluation of visual impairment due to macular degeneration and optic nerve lesions
Thomas John (Jock) Murray, OC, MD, FRCP(C), MACP, LLD(HON), DSc(Hon), FRCP(Lon): a conversation with the editor. Interview by William Clifford Roberts
Optic Nerve Degeneration and Reduced Contrast Sensitivity Due to Folic Acid Deficiency: A Behavioral and Electrophysiological Study in Rhesus Monkeys
Detection of hidden visual loss in multiple sclerosis. A comparison of pattern-reversal visual evoked potentials and contrast sensitivity
Gradiate: A radial sweep approach to measuring detailed contrast sensitivity functions from eye movements.
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Genetic Screens in iPSC-derived Brain Cells
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Alzheimer's Disease: MS4A
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Chronic Fatigue Syndrome
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Pharmacology of Proteinopathies
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Alignment-free Sequence Analysis Tools
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