Visual acuity loss and development of ocular complications in white dot syndromes: a longitudinal analysis of 3 centers

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Lara Borrego-SanzMadrid Uveitis Study Group

Abstract

To compare the clinical prognosis among selected white dot syndromes (WDS) (birdshot chorioretinopathy (BRC), multifocal choroiditis, serpiginous choroidopathy (SC), and others) and to identify risk factors of poor visual prognosis. Retrospective longitudinal cohort study including 84 patients (143 affected eyes) diagnosed with WDS between 1982 and July 2017, followed up until loss of follow-up or December 2017, and recruited from three Uveitis Clinics (Madrid Community, Spain). Our main outcome measures were temporary or permanent moderate (corrected visual acuity in the Snellen scale < 20/50) or severe (< 20/200) vision losses, and development of new ocular complications. Incidence rates (IR) of the main outcome measures were estimated per 100 eye-years. Bivariate and multivariate Cox robust regression models analyzed the association of demographic- and clinical-related variables with vision loss. SC exhibited the greatest IR of vision loss, even in the multivariate models. Previous events of vision loss, presence of choroidal neovascularization, and cataracts exhibited worse visual prognosis. Monotherapy with immunosuppressive drugs but not combine therapy was also associated with higher IR of visual loss. Regarding new ocul...Continue Reading

References

Jun 1, 1991·Ophthalmology·P L Hooper, H J Kaplan
Feb 1, 1997·Arthritis and Rheumatism·A BañaresC Hernández-García
Nov 9, 2000·British Journal of Clinical Pharmacology·A D McMahon, T M MacDonald
Jan 30, 2002·Ocular Immunology and Inflammation·E K AkpekC S Foster
May 7, 2002·American Journal of Ophthalmology·Kean T OhJames C Folk
Nov 21, 2002·Retina·Nancy J ChristmasJames C Folk
Mar 12, 2004·American Journal of Ophthalmology·David A QuillenRobert A Equi
May 4, 2004·Ophthalmology·Aniki RothovaG Seerp Baarsma
Dec 21, 2004·Acta Ophthalmologica Scandinavica·Raul N G ViannaJean Deschênes
Jul 26, 2005·American Journal of Ophthalmology·Jennifer E ThorneJohn H Kempen
Oct 1, 2005·American Journal of Ophthalmology·Douglas A JabsUNKNOWN Standardization of Uveitis Nomenclature (SUN) Working Group
Sep 1, 2007·Ocular Immunology and Inflammation·H AbrezS Sudharshan
Nov 13, 2007·American Journal of Ophthalmology·Jennifer E ThorneJames P Dunn
Sep 6, 2008·Japanese Journal of Ophthalmology·Hiroyuki ShimadaYoko Kazato
Oct 14, 2008·American Journal of Ophthalmology·Ralph D LevinsonAntoine P Brezin
Mar 10, 2011·Retina·Aniki RothovaTos T J M Berendschot
Nov 24, 2011·Ocular Immunology and Inflammation·Nakhleh E Abu-YaghiSophie J Bakri
Oct 23, 2013·Indian Journal of Ophthalmology·Kumar SaurabhJyotirmay Biswas
Dec 3, 2013·ISRN Inflammation·Courtney M Crawford, Okezie Igboeli
Dec 18, 2013·Clinical & Experimental Ophthalmology·Jason TonioloLyndell L Lim
Dec 18, 2013·JAMA Ophthalmology·Oren Tomkins-NetzerSue Lightman
Apr 1, 2016·The British Journal of Ophthalmology·Lydia AbásoloLuis Rodriguez-Rodriguez
Aug 16, 2016·American Journal of Ophthalmology·Sara TouhamiPhuc Lehoang
Mar 23, 2017·Ocular Immunology and Inflammation·Pedro Arriola-VillalobosLuis Rodriguez-Rodriguez
Mar 24, 2017·International Journal of Retina and Vitreous·Meisha L RavenJustin L Gottlieb

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Citations

Dec 29, 2020·Photodiagnosis and Photodynamic Therapy·Yuhong GanFeng Wen
Nov 27, 2021·Seminars in Neurology·Christine Greer, Marc Dinkin

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