Visual acuity loss in patients with Usher's syndrome

Archives of Ophthalmology
L PiazzaR J Anderson

Abstract

Using a life-table analysis, visual acuity loss with age was determined for a population of 106 patients with type 1 (N = 35) and type 2 (N = 71) Usher's syndrome. The cumulative percentage of patients maintaining visual acuity of 6/12 (20/40) or better in at least one eye by age 29 years was 69% for type 1 patients and 94% for type 2 patients. The cumulative percentage maintaining visual acuity of 6/24 (20/80) or better at this age was 89% for type 1 and 98% for type 2 patients. Within each subtype, the cumulative percentage maintaining 6/60 (20/200) or better was similar to the percentage maintaining 6/24 (20/80) or better. Knowledge of these data provides an objective basis for counseling patients with Usher's syndrome about their probability of developing loss of central visual acuity with age.

Citations

Jan 1, 1997·The British Journal of Ophthalmology·C I HopeA R Fielder
May 9, 2008·Human Molecular Genetics·Samuel G JacobsonDavid S Williams
Jan 1, 1995·International Ophthalmology·L PakarinenH Puhakka
Nov 10, 2001·Annual Review of Genomics and Human Genetics·C Petit
Apr 16, 2002·Acta Ophthalmologica Scandinavica·Ekaterini T TsilouMuriel I Kaiser-Kupfer
Jul 18, 2018·Current Eye Research·Anne KurtenbachEberhart Zrenner
Mar 1, 1994·American Journal of Medical Genetics·R J SmithL Tranebjaerg
Aug 2, 2006·Acta Ophthalmologica Scandinavica·André M SadeghiClaes Möller
Dec 2, 2005·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Godelieve W J A DamenEmmanuel A M Mylanus
Feb 1, 2006·Acta Ophthalmologica Scandinavica·Rutger F PlantingaAugust F Deutman
Feb 3, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·T P NikolopoulosG M O'Donoghue
Jun 15, 2007·Retina·Gerald A FishmanWilliam Kimberling
Mar 1, 1990·Ophthalmic Paediatrics and Genetics·S Samuelson, J Zahn
Dec 1, 1995·Ophthalmic Genetics·A Van AaremC W Cremers
Mar 27, 2004·Acta Ophthalmologica Scandinavica·Ronald J E PenningsAugust F Deutman
Oct 1, 1991·Clinical Genetics·M L TamayoJ C Silva
Nov 1, 1988·Survey of Ophthalmology·R A Pagon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.