Visual acuity outcome and predictive factors after bevacizumab for central retinal vein occlusion

European Journal of Ophthalmology
Vincent DaienChristelle Schneider

Abstract

To evaluate the 12-month outcome and predictive factors of visual acuity (VA) changes following bevacizumab therapy for central retinal vein occlusion (CRVO). A total of 50 eyes from 50 patients with CRVO were consecutively included in this prospective study. Predictive factors were assessed by comparing baseline characteristics of patients classified into 3 groups: those showing a decrease in VA; those displaying a change in Early Treatment Diabetic Retinopathy Study (ETDRS) letter score between 0 and 15; and those in whom an increase in VA =15 letters was achieved. Baseline variables considered in the analyses of predictive factors were demographic and clinical characteristics. Mean baseline ETDRS letter score was 20±12 and mean macular thickness was 575.1±152.7 µm. Mean final ETDRS letter score improved significantly, reaching 27±20, p=0.04, while mean macular thickness decreased significantly to 391.1±229.6 µm, p<0.001. The predictive factors associated with an increase in VA =15 ETDRS letters were younger age (p=0.002), shorter duration of symptoms before treatment initiation (p=0.001), and a higher visual acuity pretreatment (p=0.004). The frequency of ischemic CRVO and low vision at baseline was higher among nonresponsiv...Continue Reading

References

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Citations

Sep 16, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Kai JanuschowskiGesine B Szurman
Mar 1, 2016·Current Ophthalmology Reports·Mariana R Thorell, Raquel Goldhardt
Oct 9, 2014·Neuro-ophthalmology·İnci GüngörNurşen Arıtürk
Oct 15, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Dan Călugăru, Mihai Călugăru
Feb 11, 2015·Current Eye Research·Bingzhen LiLin Zhao
Mar 21, 2017·European Journal of Ophthalmology·Sara Vaz-PereiraRita Flores
Oct 12, 2020·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Karan S DewanRishi P Singh

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