Visual Acuity Outcomes in Diabetic Macular Edema With Fluocinolone Acetonide 0.2 μg/Day Versus Ranibizumab Plus Deferred Laser (DRCR Protocol I)

Ophthalmic Surgery, Lasers & Imaging Retina
Michael A SingerBaruch D Kuppermann

Abstract

Visual outcomes of the FAME study (0.2 μg/day fluocinolone acetonide [FAc]) and Protocol I (0.5 mg ranibizumab plus deferred laser) were compared using the area under the curve (AUC) analysis method. Best-corrected visual acuity (BCVA) data collected during a period of 3 years of follow-up for patients enrolled in FAME or Protocol I were used to calculate AUC of the change in BCVA over a time curve. In the overall population, there was a greater treatment effect for ranibizumab plus deferred laser compared with FAc. However, for subgroups of pseudophakic eyes, eyes with chronic diabetic macular edema (DME), and pseudophakic eyes with chronic DME, ranibizumab plus deferred laser and FAc were not found to be significantly different. The ranibizumab group received a median of 14 injections during a 36-month period compared with a mean of 1.3 injections in the FAc group. In pseudophakic and chronic DME subgroups, FAc was comparable to ranibizumab plus deferred laser with fewer injections. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:698-706.].

References

Mar 12, 2010·Investigative Ophthalmology & Visual Science·Inna V GlybinaRaymond Iezzi
Apr 30, 2010·Ophthalmology·UNKNOWN Diabetic Retinopathy Clinical Research NetworkJennifer K Sun
Apr 5, 2011·Ophthalmology·Peter A CampochiaroUNKNOWN FAME Study Group
Jun 4, 2011·Progress in Retinal and Eye Research·Johnny Tang, Timothy S Kern
Feb 4, 2012·Diabetes Care·Joanne W Y YauUNKNOWN Meta-Analysis for Eye Disease (META-EYE) Study Group
Dec 3, 2014·Ophthalmology·Michael J ElmanUNKNOWN Diabetic Retinopathy Clinical Research Network
Nov 14, 2015·JAMA : the Journal of the American Medical Association·UNKNOWN Writing Committee for the Diabetic Retinopathy Clinical Research NetworkRoy W Beck
Apr 28, 2017·JAMA Ophthalmology·Susan B BresslerUNKNOWN Diabetic Retinopathy Clinical Research Network

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Citations

Apr 30, 2020·Ophthalmic Surgery, Lasers & Imaging Retina·Dimosthenis MantopoulosDaniel B Roth
Jan 17, 2020·Taiwan Journal of Ophthalmology·Jorge Chawan-SaadLihteh Wu

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