Visual Arrestin 1 acts as a modulator for N-ethylmaleimide-sensitive factor in the photoreceptor synapse.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Shun-Ping HuangCheryl M Craft

Abstract

In the G-protein-coupled receptor phototransduction cascade, visual Arrestin 1 (Arr1) binds to and deactivates phosphorylated light-activated opsins, a process that is critical for effective recovery and normal vision. In this report, we discovered a novel synaptic interaction between Arr1 and N-ethylmaleimide-sensitive factor (NSF) that is enhanced in a dark environment when mouse photoreceptors are depolarized and the rate of exocytosis is elevated. In the photoreceptor synapse, NSF functions to sustain a higher rate of exocytosis, in addition to the compensatory endocytosis to retrieve and to recycle vesicle membrane and synaptic proteins. Not only does Arr1 bind to the junction of NSF N-terminal and its first ATPase domains in an ATP-dependent manner in vitro, but Arr1 also enhances both NSF ATPase and NSF disassembly activities. In in vivo experiments in mouse retinas with the Arr1 gene knocked out, the expression levels of NSF and other synapse-enriched components, including vGLUT1 (vesicular glutamate transporter 1), EAAT5 (excitatory amino acid transporter 5), and VAMP2 (vesicle-associated membrane protein 2), are markedly reduced, which leads to a substantial decrease in the exocytosis rate with FM1-43. Thus, we propos...Continue Reading

References

Jan 1, 1992·Cold Spring Harbor Symposia on Quantitative Biology·R J LefkowitzM G Caron
Jan 1, 1988·Journal of Neuroscience Research·J P Whelan, J F McGinnis
Dec 8, 1995·The Journal of Biological Chemistry·E E NagiecS W Whiteheart
Apr 3, 1995·FEBS Letters·C M Craft, D H Whitmore
Sep 5, 1994·FEBS Letters·D Roth, R D Burgoyne
Aug 23, 1996·The Journal of Biological Chemistry·A BanerjeeT F Martin
Apr 18, 1998·The Journal of Biological Chemistry·A W GagnonJ L Benovic
Aug 11, 1998·Neuron·A NishimuneJ M Henley
Apr 10, 1999·The Journal of Biological Chemistry·P H McDonaldR J Lefkowitz
Jul 13, 2000·Microscopy Research and Technique·C W Morgans
Feb 22, 2001·Neuron·H von Gersdorff
Aug 31, 2002·Biophysical Journal·Chunhe ChenYiannis Koutalos
Oct 16, 2003·Science's STKE : Signal Transduction Knowledge Environment·Vadim Y Arshavsky
Aug 24, 2004·Nature Cell Biology·Huong HuynhTomas Mustelin
Feb 1, 2005·The Journal of Comparative Neurology·Alejandro CaicedoScott W Cousins
Apr 23, 2005·Science·Robert J Lefkowitz, Sudha K Shenoy
Jul 20, 2005·Progress in Retinal and Eye Research·Ruth HeidelbergerPaul Witkovsky
Nov 18, 2005·Journal of Molecular Biology·R Bryan SuttonVsevolod V Gurevich
Nov 23, 2005·Neuron·Sue-Yeon ChoiRichard H Kramer
Jan 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marie E BurnsJeannie Chen
Jul 21, 2006·BMC Microbiology·Timothy K GallaherRodrigo Aguilera
Sep 16, 2006·The Journal of Physiology·Eric WersingerMichel J Roux
Jan 26, 2007·Advances in Experimental Medicine and Biology·W Clay SmithAstra Dinculescu
Apr 27, 2007·Investigative Ophthalmology & Visual Science·Sanny ChanJeannie Chen
Jul 6, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Juliette JohnsonDavid R Copenhagen
Oct 24, 2007·Molecular Neurobiology·Wallace B Thoreson
Aug 15, 2008·Neuron·Sergei S NikonovCheryl M Craft
Dec 19, 2009·Investigative Ophthalmology & Visual Science·Bruce M BrownCheryl M Craft

❮ Previous
Next ❯

Citations

Feb 4, 2011·Biochemistry·Miyeon KimVsevolod V Gurevich
Dec 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Mehdi NajafiPeter D Calvert
Sep 8, 2015·Progress in Retinal and Eye Research·Bruce A BerkowitzRobin Roberts
Apr 9, 2013·Progress in Retinal and Eye Research·Jillian N PearringVadim Y Arshavsky
Aug 10, 2011·Progress in Retinal and Eye Research·Vsevolod V GurevichEugenia V Gurevich
Aug 28, 2012·Vision Research·Mehdi Najafi, Peter D Calvert
Jul 3, 2013·Cellular and Molecular Life Sciences : CMLS·Tyler S SmithW Clay Smith
Jun 20, 2017·Pharmacological Reviews·Yuri K Peterson, Louis M Luttrell
Oct 30, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bruce A BerkowitzRobin Roberts
Aug 20, 2019·Cellular and Molecular Life Sciences : CMLS·Vsevolod V Gurevich, Eugenia V Gurevich
Dec 3, 2014·Current Protocols in Pharmacology·Vsevolod V Gurevich, Eugenia V Gurevich
Apr 3, 2020·The Journal of Biological Chemistry·Connie Jaqueline MirandaW Clay Smith
Feb 23, 2021·Frontiers in Cell and Developmental Biology·Cassandra L BarnesPeter D Calvert
Apr 22, 2021·Pflügers Archiv : European journal of physiology·Himanshu MalhotraPeter D Calvert
Jun 21, 2015·Disease Models & Mechanisms·Shun-Ping HuangRong-Kung Tsai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.