Visual attention in autism families: 'unaffected' sibs share atypical frontal activation.

Journal of Child Psychology and Psychiatry, and Allied Disciplines
Matthew K BelmonteS Baron-Cohen

Abstract

In addition to their more clinically evident abnormalities of social cognition, people with autism spectrum conditions (ASC) manifest perturbations of attention and sensory perception which may offer insights into the underlying neural abnormalities. Similar autistic traits in ASC relatives without a diagnosis suggest a continuity between clinically affected and unaffected family members. We applied fMRI in the context of a non-social task of visual attention in order to determine whether this continuity persists at the level of brain physiology. Both boys with ASC and clinically unaffected brothers of people with ASC were impaired at a visual divided-attention task demanding conjunction of attributes from rapidly and simultaneously presented, spatially disjoint stimuli and suppression of spatially intervening distractors. In addition, both groups in comparison to controls manifested atypical fronto-cerebellar activation as a function of distractor congruence, and the degree of this frontal atypicality correlated with psychometric measures of autistic traits in ASC and sibs. Despite these resemblances between the ASC and sib groups, an exploratory, hypothesis-generating analysis of correlations across brain regions revealed a d...Continue Reading

References

Jan 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L C MaasP F Renshaw
Nov 1, 1996·Journal of the International Neuropsychological Society : JINS·J TownsendE Courchesne
Apr 21, 1998·Journal of Cardiac Failure·S OhtaniS Sasayama
Jun 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R B BuxtonL R Frank
Apr 9, 1999·Nature Neuroscience·N HadjikhaniR B Tootell
Aug 5, 1999·Journal of Child Psychology and Psychiatry, and Allied Disciplines·K PlaistedL Rees
Sep 11, 1999·Neuron·E Wojciulik, N Kanwisher
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·K J Friston, C Büchel
Jul 27, 2000·Human Brain Mapping·J L LancasterP T Fox
Apr 26, 2001·Journal of Child Psychology and Psychiatry, and Allied Disciplines·F HappéU Frith
May 28, 2002·Development and Psychopathology·Jon BrockGina Rippon
Sep 28, 2002·Development and Psychopathology·Mark H JohnsonAnnette Karmiloff-Smith
Feb 18, 2003·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Tania A Mann, Peter Walker
Apr 5, 2003·Journal of Cognitive Neuroscience·Armando BertoneJocelyn Faubert
May 14, 2003·Archives of General Psychiatry·John N Constantino, Richard D Todd
Jun 5, 2003·NeuroImage·Matthew K Belmonte, Deborah A Yurgelun-Todd
Sep 10, 2003·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Peter Mundy
Oct 14, 2003·Child Development·Glenda AndrewsToni Jones
Oct 17, 2003·Brain Research. Cognitive Brain Research·Matthew K Belmonte, Deborah A Yurgelun-Todd
Oct 22, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew K BelmonteSara J Webb
Jan 18, 2005·NeuroImage·Hideya KoshinoMarcel Adam Just
Feb 3, 2005·Psychological Science·John T SerencesSteven Yantis
Mar 8, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Lonnie ZwaigenbaumPeter Szatmari
Apr 22, 2005·Developmental Neuropsychology·Frank HaistJeanne Townsend
Jun 17, 2005·Brain : a Journal of Neurology·Armando BertoneJocelyn Faubert
Aug 24, 2005·NeuroImage·Marie GomotSimon Baron-Cohen
Aug 27, 2005·Journal of Autism and Developmental Disorders·M R Woodbury-SmithS Baron-Cohen
Jan 7, 2006·Journal of Autism and Developmental Disorders·Grace IarocciJames T Enns
Feb 2, 2006·The American Journal of Psychiatry·John N ConstantinoRichard D Todd
Feb 3, 2006·Journal of Autism and Developmental Disorders·Laurent MottronJake Burack
Feb 8, 2006·Brain and Cognition·Simon Baron-CohenEd Bullmore
Mar 23, 2006·Journal of Autism and Developmental Disorders·Simon Baron-CohenSally Wheelwright
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Daniel P KennedyEric Courchesne

❮ Previous
Next ❯

Citations

Dec 21, 2013·Journal of Autism and Developmental Disorders·Luca RonconiEloisa Valenza
Nov 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Martha D KaiserKevin A Pelphrey
Oct 19, 2011·Brain : a Journal of Neurology·Jeffrey S AndersonJanet E Lainhart
Oct 8, 2013·Psychopharmacology·Barbara RuggeriAntonio M Persico
Mar 5, 2013·Journal of the American Academy of Child and Adolescent Psychiatry·Daniel P DicksteinRowland P Barrett
Apr 17, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Luca RonconiAndrea Facoetti
Feb 22, 2012·Biological Psychiatry·Ofer Yizhar
Dec 7, 2010·Neurobiology of Disease·Carla LintasAntonio M Persico
Jan 31, 2012·Current Biology : CB·Mayada ElsabbaghUNKNOWN BASIS Team
Dec 18, 2013·Behavioural Brain Research·Caroline G M de TheijeAletta D Kraneveld
Nov 17, 2012·Behavioural Brain Research·Rebecca M Jones, Catherine Lord
Dec 5, 2012·Neuroscience and Biobehavioral Reviews·Brandon KeehnJeanne Townsend
Jun 11, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Kentaroh TakagakiGholam K Motamedi
May 25, 2016·Schizophrenia Bulletin·Ahmad Abu-AkelCarmel Mevorach
Sep 7, 2016·Research in Developmental Disabilities·Alice ChinelloEloisa Valenza
Apr 5, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Tatiana A StroganovaYuriy V Obukhov
Oct 27, 2017·Journal of Clinical and Experimental Neuropsychology·Sanam J LalaniJanet E Lainhart
Feb 18, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jennifer J DoneganDaniel J Lodge
Sep 26, 2013·Journal of Neurodevelopmental Disorders·Nava Levit-BinnunYulia Golland
Mar 14, 2014·Development and Psychopathology·Steven D StaggPamela Heaton
Aug 12, 2018·Scientific Reports·Virginia Carter LenoJames C McPartland
Dec 7, 2014·Journal of Autism and Developmental Disorders·Jane E JosephRamesh S Bhatt
Aug 5, 2017·Science Translational Medicine·Aslihan SelimbeyogluKarl Deisseroth
Oct 6, 2016·Journal of Autism and Developmental Disorders·Claudia L HiltonJohn N Constantino
Mar 28, 2019·Molecular Neurobiology·Livia La BarberaParaskevi Krashia
May 7, 2019·Frontiers in Endocrinology·Joris H J van SadelhoffAletta D Kraneveld
Jan 1, 2014·Journal of Neurodevelopmental Disorders·Anne SeeryCharles A Nelson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.