Visual cortical organization at the single axon level: a beginning

Neuroscience Research
K S Rockland

Abstract

Single axon analysis of visual cortical connections is an important extension of previous anterograde studies using 3H-amino acids or wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP). The higher resolution tracers-Phaseolus vulgaris-leucoagglutinin (PHA-L), biocytin, biotinylated dextran amine (BDA) and dextran-conjugates-have already produced new results, simply by providing improved visualization, concerning laminar definition and possible subtypes of connections, as well as the beginning of a database of morphometrics and microstructure. The comparative approach, comparing geniculocortical terminations and cortical connections across several areas, has suggested both specific structural-functional correlations (for example, in extrastriate area MT/V5) and more subtle, possibly gradient-wise variations. Likely future directions for this line of research include more direct correlations of axon geometry with functional architectures, investigations of microcircuitry at the level of electron or confocal microscopy, anatomical and functional investigations of connectional convergence and interactions, and, not least, a more comprehensive database.

References

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Citations

Sep 27, 2003·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Kathleen S Rockland, Hisayuki Ojima
Jul 19, 2005·Annual Review of Neuroscience·Richard T Born, David C Bradley
Nov 17, 2006·Journal of Neurophysiology·Margaret S Livingstone, Bevil R Conway
Jun 18, 2004·Journal of Cognitive Neuroscience·A RodriguezR Granger
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Samuel S-H WangKrysta D Wyatt
Mar 26, 2004·Cognitive, Affective & Behavioral Neuroscience·Tor D Wager, Edward E Smith
Dec 22, 2015·Neuron·Katrin Amunts, Karl Zilles
Jun 6, 2008·Brain Research·Stephen Grossberg, Massimiliano Versace
Jan 15, 2008·Journal of Neuroscience Methods·Manuel F CasanovaAdel S Elmaghraby
Jan 12, 2020·Brain Structure & Function·Kathleen S Rockland
Oct 3, 2017·Visual Neuroscience·N A ZhouMartha E Bickford

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