Visual cue-related activity of cells in the medial entorhinal cortex during navigation in virtual reality.

ELife
Amina KinkhabwalaDavid W Tank

Abstract

During spatial navigation, animals use self-motion to estimate positions through path integration. However, estimation errors accumulate over time and it is unclear how they are corrected. Here we report a new cell class ('cue cell') encoding visual cues that could be used to correct errors in path integration in mouse medial entorhinal cortex (MEC). During virtual navigation, individual cue cells exhibited firing fields only near visual cues and their population response formed sequences repeated at each cue. These cells consistently responded to cues across multiple environments. On a track with cues on left and right sides, most cue cells only responded to cues on one side. During navigation in a real arena, they showed spatially stable activity and accounted for 32% of unidentified, spatially stable MEC cells. These cue cell properties demonstrate that the MEC contains a code representing spatial landmarks, which could be important for error correction during path integration.

References

Mar 1, 1992·Behavioral and Neural Biology·J S TaubeC W Cotman
Jun 13, 2003·Biomedical Engineering Online·Thomas A PologrutoKarel Svoboda
Jun 21, 2005·Nature·Torkel HaftingEdvard I Moser
Apr 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark C Fuhs, David S Touretzky
Jul 22, 2006·Nature Reviews. Neuroscience·Bruce L McNaughtonMay-Britt Moser
Feb 27, 2007·Nature·Marianne FyhnEdvard I Moser
Sep 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jonathan R WhitlockEdvard I Moser
Dec 20, 2008·Science·Trygve SolstadEdvard I Moser
Jan 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin J ClarkJeffrey S Taube
Feb 21, 2009·PLoS Computational Biology·Yoram Burak, Ila R Fiete
Apr 22, 2009·Journal of Visualized Experiments : JoVE·Fabian KloostermanMatthew A Wilson
Jun 3, 2009·Behavioral Neuroscience·Benjamin J Clark, Jeffrey S Taube
Aug 7, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Colin LeverNeil Burgess
Sep 15, 2009·Nature Neuroscience·Dori DerdikmanEdvard I Moser
Sep 26, 2009·Neuron·Eran A MukamelMark J Schnitzer
Oct 16, 2009·Nature·Christopher D HarveyDavid W Tank
Dec 17, 2009·Hippocampus·Nachum Ulanovsky, Cynthia F Moss
Apr 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin J ClarkJeffrey S Taube
Jul 27, 2010·Nature Neuroscience·Charlotte N BoccaraMay-Britt Moser
Aug 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Asaf TsoarNachum Ulanovsky
Feb 12, 2013·Nature·Cristina DomnisoruDavid W Tank
Mar 1, 2013·Hippocampus·Sachin S Deshmukh, James J Knierim
May 21, 2013·Nature·Mattia RigottiStefano Fusi
Jul 16, 2013·Nature Neuroscience·Kijung YoonIla R Fiete
Jul 23, 2013·Nature·Tsai-Wen ChenDouglas S Kim
Oct 10, 2013·The Behavioral and Brain Sciences·Homare YamahachiEdvard I Moser
Nov 10, 2013·Nature·Valerio ManteWilliam T Newsome
Dec 25, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sarah StewartColin Lever
Jan 17, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alon RubinNachum Ulanovsky
Jan 21, 2014·Current Biology : CB·Lisa M GiocomoEdvard I Moser
Apr 17, 2014·Current Biology : CB·C Barry, N Burgess
Sep 25, 2014·PloS One·Hod DanaKarel Svoboda
Dec 4, 2014·Nature·Arseny FinkelsteinNachum Ulanovsky
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ryan J LowDavid W Tank
Jan 21, 2015·Nature Reviews. Neuroscience·Maya Geva-SagivNachum Ulanovsky
Feb 13, 2015·Nature·Tor StensolaEdvard I Moser
Feb 13, 2015·Nature·Julija KrupicJohn O'Keefe

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