Abstract
The nucleus accumbens septi (Acc) is thought to be involved in the control of cognitive processes and to be implicated in the pathophysiology of schizophrenia. Because perceptual-cognitive distortions are a core symptom in schizophrenia, any evidence that the Acc intervenes in a sensory recognition task in an animal species would be of interest. Pigeons were instrumentally trained to discriminate visual shapes. The acute effects of drug microinjections into the Acc on the discrimination of the training shapes, on the correction responding after errors, and on the generalisation to different shapes were examined. The effects of conduction blockade with lidocaine, glutamatergic blockade with 7-aminophosphonoheptanoic acid, and dopaminergic stimulation with apomorphine on behavioural performance were tested. No effects were observed with lidocaine and apomorphine. A significant and reversible performance disruption to near chance levels was obtained after aminophosphonoheptanoic acid injections into the Acc. It appears that a glutamatergic blockade of the Acc interferes with the visual discrimination processes of pigeons.
References
Feb 1, 1992·Biological Psychiatry·S K Min, B H Oh
Mar 15, 1991·The Journal of Comparative Neurology·P R HofP J Magistretti
Nov 26, 1991·Behavioural Brain Research·P J ReadingT W Robbins
Jan 1, 1990·Schizophrenia Bulletin·M Carlsson, A Carlsson
May 1, 1986·The Journal of Comparative Neurology·C A Kitt, S E Brauth
Feb 1, 1989·Clinical Neuropharmacology·S I DeutschJ M Morihisa
Aug 14, 1989·Brain Research·G B SchacterG J Mogenson
Jan 1, 1989·Behavioural Brain Research·L E AnnettT W Robbins
Jan 26, 1988·Brain Research·M M Dietl, J M Palacios
Jun 21, 1988·Brain Research·U Lindenblatt, J D Delius
May 29, 1981·Neuroscience Letters·M N PerkinsK Curry
Sep 10, 1984·The Journal of Comparative Neurology·A ReinerH J Karten
Sep 17, 1984·Brain Research·K HallC A Kitt
Jul 1, 1982·Medical Hypotheses·R B Chronister, J F DeFrance
Sep 1, 1995·Neuropsychologia·J A Gray
Mar 27, 1995·The Journal of Comparative Neurology·C L VeenmanA Reiner
Jun 1, 1994·Behavioral Neuroscience·J K Seamans, A G Phillips
Apr 1, 1994·Progress in Neurobiology·C M PennartzF H Lopes da Silva
Apr 18, 1994·Behavioural Brain Research·J D Salamone
Oct 1, 1995·Neuropsychologia·A KritikosJ A Bradshaw
Jan 1, 1995·Journal of Neural Transmission. General Section·A SvenssonA Carlsson
Citations
Apr 16, 2004·Behavioural Brain Research·Martin J AcerboJuan D Delius
Mar 21, 2003·Brain Research·Amanda A Da SilvaMarta A Paschoalini
Jun 5, 2002·Physiology & Behavior·Gabriel MartínezPascual A Gargiulo
Jun 5, 2002·Physiology & Behavior·Gabriel MartínezPascual A Gargiulo
Oct 19, 2002·Behavioural Brain Research·Martín J AcerboJuan D Delius
Jul 23, 1999·Annals of the New York Academy of Sciences·P A GargiuloA I Landa
Jun 7, 2014·Pharmacological Reports : PR·Pascual Ángel Gargiulo, Adriana Inés Landa De Gargiulo
Aug 21, 2013·Pharmacological Reports : PR·Luis H Llano LópezPascual A Gargiulo
Jun 28, 2005·Pharmacology, Biochemistry, and Behavior·P A GargiuloJ D Delius
Oct 28, 2016·Behavioural Brain Research·Soleil García-BritoPilar Segura-Torres
Sep 22, 2005·Journal of Psychopharmacology·Ralf-Peter Behrendt
Sep 16, 2006·The Journal of Comparative Neurology·Yasuro AtojiJ Martin Wild
Jul 10, 2007·Journal of Neural Transmission·G BaiardiP A Gargiulo
Jul 1, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Luis H Llano LópezPascual A Gargiulo
Jun 16, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Augusto P I GargiuloPascual A Gargiulo
Sep 29, 2019·Scientific Reports·Juan D Delius, Julia A M Delius
Jan 14, 2020·Neuropsychobiology·Augusto P I GargiuloPascual Ángel Gargiulo