Visual disturbances during prolonged space missions.

Current Opinion in Ophthalmology
Emily A Khossravi, Alan R Hargens

Abstract

During prolonged spaceflight, astronauts often experience ocular changes, due to constant head-ward fluid shifts in space as compared with Earth. This article reviews symptoms, likely causes, and potential solutions, such as lower body negative pressure, to counteract space-associated neuroocular syndrome (SANS). Low gravity conditions and other aspects of spaceflight affect the eye detrimentally, causing SANS which is characterized by optic disc edema, choroidal thickening, cotton wool spots, and a hyperopic shift. SANS is probably caused by altered hemodynamic flows in the head and neck as well as mildly elevated intracranial and intraocular pressures. Carbon dioxide and other chemicals in space-craft may influence SANS as well. SANS may be counteracted by using lower body negative pressure, thigh cuffs, spacecraft engineering, and/or artificial gravity by a centrifuge. Prolonged space missions are associated with optic disc edema, choroidal thickening, cotton wool spots, and a hyperopic shift. Possible causes and countermeasures are currently being researched to reduce the risk of SANS. Although many countermeasures to SANS are under investigation lower body negative pressure exhibits great promise in counteracting the headw...Continue Reading

References

Jul 21, 2009·Respiratory Physiology & Neurobiology·Alan R Hargens, Sara Richardson
Feb 2, 2013·Survey of Ophthalmology·Giovanni TaibbiGianmarco Vizzeri
Mar 26, 2016·Journal of Applied Physiology·Polona Jaki MekjavicIgor B Mekjavic
May 27, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sara R ZwartScott M Smith
Nov 2, 2017·The New England Journal of Medicine·Donna R RobertsMichael U Antonucci
Nov 21, 2017·Ophthalmology·Siva BalasubramanianBrandon R Macias
Mar 13, 2018·Eye·Andrew G LeeWilliam J Tarver
Mar 23, 2018·Aerospace Medicine and Human Performance·Karina Marshall-GoebelEric M Bershad
Jul 7, 2018·JAMA Ophthalmology·Ari ShinojimaSatoru Tada
Oct 5, 2018·The Journal of Physiology·Lonnie G PetersenBenjamin D Levine
Nov 30, 2018·Aerospace Medicine and Human Performance·Peter WostynPeter Paul De Deyn
Jun 5, 2019·Journal of Glaucoma·Alex S HuangBrandon R Macias
Jul 25, 2019·Aerospace Medicine and Human Performance·Amelia A RomoserJ Torin McCoy
Aug 21, 2019·Aerospace Medicine and Human Performance·Robert R ScullyValerie E Ryder
Oct 22, 2019·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Laura A GaldamezWilliam J Tarver
Nov 14, 2019·JAMA Network Open·Karina Marshall-GoebelMichael B Stenger
Nov 25, 2019·Ophthalmology·Michael B StengerAlex S Huang
Jan 31, 2020·Frontiers in Systems Neuroscience·Kathleen E HupfeldRachael D Seidler
Apr 15, 2020·Radiology·Larry A KramerBrandon R Macias

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