Visual Experience Is Required for the Development of Eye Movement Maps in the Mouse Superior Colliculus

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Lupeng WangJianhua Cang

Abstract

Topographic maps are a fundamental feature of the brain's representations of the sensory environment as well as an efficient way to organize motor control networks. Although great progress has been made in our understanding of sensory map development, very little is known about how topographic representations for motor control develop and interface with sensory maps. Here we map the representation for eye movements in the superior colliculus (SC) in awake mice. As stimulation sites were sampled along the anterior-posterior axis, small amplitude, nasally directed (ipsiversive) saccadic eye movements were evoked by microstimulation in anterior SC, followed by a smooth progression to large, temporally directed (contraversive) movements in posterior SC. This progressive change of movement amplitude and direction is consistent with the global polarity of the retinotopic map in the superficial SC, just as in primates and cats. We then investigated the role of visual experience in the development of eye movement map by studying mice reared in complete darkness. Saccades evoked by SC stimulation as well as spontaneous saccadic eye movements were larger in the dark-reared mice, indicating that visual experience is required to fine-tune ...Continue Reading

Citations

Aug 17, 2016·The European Journal of Neuroscience·Masatoshi Kasai, Tadashi Isa
Jun 1, 2018·Annual Review of Vision Science·Jianhua CangXiaorong Liu
Apr 18, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Martin O BohlenSusan Warren
Jun 16, 2017·Annual Review of Vision Science·Michele A Basso, Paul J May
Aug 5, 2017·Annual Review of Neuroscience·Tania A SeabrookAndrew D Huberman
Feb 23, 2020·The Journal of Comparative Neurology·Ted K DoykosGidon Felsen
Oct 24, 2018·Nature Neuroscience·Jason M SamondsNicholas J Priebe
Jan 30, 2021·Nature Communications·Caitlin S MalloryLisa M Giocomo
Jul 22, 2021·Nature Communications·Meizhu HuangPeng Cao
Sep 23, 2021·Journal of Neurophysiology·Jaclyn Essig, Gidon Felsen

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