Visual experience regulates Kv3.1b and Kv3.2 expression in developing rat visual cortex

Neuroscience
J Grabert, P Wahle

Abstract

Among the GABAergic neocortical interneurons, parvalbumin-containing fast-spiking (FS) basket cells are essential mediators of feed-forward inhibition, network synchrony and oscillations, and timing of the critical period for sensory plasticity. The FS phenotype matures after birth. It depends on the expression of the voltage-gated potassium channels Kv3.1b/3.2 which mediate the fast membrane repolarization necessary for firing fast action potentials at high frequencies. We have now tested in rat visual cortex if visual deprivation affects the Kv3 expression. During normal development, Kv3.1b/3.2 mRNA and protein expression increased in rat visual cortex reaching adult levels around P20. Dark rearing from birth neither prevented nor delayed the upregulation. Rather unexpectedly, the expression of Kv3.1b protein and Kv3.2 mRNA and protein increased to higher levels from the third postnatal week onwards. Triple-labeling revealed that in dark-reared visual cortex Kv3.2 was upregulated in parvalbuminergic interneurons in supragranular layers which in normal animals rarely display Kv3.2 expression. Recovery from dark rearing normalized Kv3.2 expression. This showed that visual experience influences the Kv3 expression. The results su...Continue Reading

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Citations

Feb 11, 2011·Journal of Neurophysiology·Ingrid van Welie, Sascha du Lac
Dec 3, 2013·FEBS Letters·Seong Han BaeKang-Sik Park
Jul 29, 2010·Journal of Neurodevelopmental Disorders·Nadine GogollaTakao K Hensch
Sep 15, 2017·Physiological Reviews·Leonard K Kaczmarek, Yalan Zhang
Apr 20, 2021·Neuroscience Research·Yoshi-Taka MatsudaTakao K Hensch

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