Visual field defects and pituitary enlargement in primary hypothyroidism

The Journal of Clinical Endocrinology and Metabolism
K YamamotoS Yoshida

Abstract

In 14 patients with overt primary hypothyroidism, we examined visual fields by Goldmann's isopter perimetry. An unexpectedly high incidence (10 patients, 71.4%) of visual field defects was found. Two patients complained of visual failure, whereas 12 had no subjective symptoms. The extent of visual field change varied over a wide range, from early chiasmal compression to apparent bitemporal hemianopsia. The abnormality was characteristically restriction in the central visual field; peripheral vision was less often affected. The sella turcica was significantly enlarged in these patients as compared to controls. The volume of the sella turcica correlated significantly with both basal serum TSH and total pituitary reserve of TSH (r = 0.82, P less than 0.001). There was no correlation between the extent of visual field change and the volume of the sella turcica or pituitary TSH reserve. Of 10 patients with visual field defects, 8 improved during 1-4 months of T4 replacement. In 2 patients, however, the visual field defect deteriorated during replacement. The deterioration occurred when serum TSH levels had decreased to about 50% and 20% of pretreatment values, respectively. The peak serum TSH after TRH stimulation was higher at the ...Continue Reading

Citations

Jan 1, 1985·Fertility and Sterility·R E Blackwell
Sep 23, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology·L ChaiebM Allegue
Dec 4, 2012·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Brent L FinleyDennis J Paustenbach
Nov 1, 1987·Surgical Neurology·Z EliasT W Bouldin
Apr 1, 1986·The Journal of Pediatrics·S H LaFranchiP L Krainz
Jul 1, 1985·The American Journal of Medicine·P A BastenieL Vanhaelst
Jul 26, 2000·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·A Levy
May 3, 2011·Journal of Neurosurgery. Pediatrics·Kristian Aquilina, Frederick A Boop
Mar 1, 1997·The Journal of Clinical Endocrinology and Metabolism·N J SarlisM C Skarulis
Jan 1, 1986·Cancer Metastasis Reviews·J R Dollar, R E Blackwell
Feb 1, 1988·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J D FarleyE A Ryan
Apr 3, 2020·Pediatrics in Review·Rebecca SteuartLisa E Herrmann
Jan 11, 2005·Arquivos brasileiros de endocrinologia e metabologia·Carolina C R BetônicoPaulo Tannus Jorge
Mar 10, 2006·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Nahla M KhawajaKamel M Ajlouni
May 1, 2021·Journal of the Endocrine Society·Juanita K HodaxJose Bernardo Quintos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.