Visual function in infants with West syndrome: correlation with EEG patterns

Epilepsia
Teresa RandòFrancesco Guzzetta

Abstract

Several studies have reported behavioral and electrophysiological evidence of visual impairment during the active stage of West syndrome. The underlying mechanisms are, however, poorly understood, and little has been reported about the correlation between visual impairment, EEG patterns, and brain lesions. The aim of the study was to assess visual function at the onset of spasm and 2 months thereafter and relate visual findings to brain lesions and EEG features. Twenty-five infants with West syndrome were enrolled and studied with (a) a full clinical assessment including a battery of tests specifically designed to assess visual function, (b) a video-polygraphic study, and (c) brain magnetic resonance imaging (MRI). Besides brain neuroimaging and EEG comparison with visual function, an intra-EEG analysis was performed to investigate the possible relation of EEG patterns to fluctuating visual behavior (fixation and following). Twenty-two children had at least one abnormal result on one or more of the tests assessing visual function at T0. Visual impairment at the spasm onset was related to the sleep disorganization rather than to the hypsarrhythmic pattern in awake EEG. After 2 months, both EEG features become significantly linke...Continue Reading

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Citations

Oct 27, 2007·Neuropsychology Review·William S MacAllister, Sarah G Schaffer
Nov 16, 2006·Epilepsia·Franco Guzzetta
Jan 14, 2010·Epilepsia·Paola De RoseEugenio Mercuri
Dec 5, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·Daniela RicciEugenio Mercuri
Dec 8, 2007·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Francesco GuzzettaFrancesca Tinelli
Jun 9, 2007·Brain & Development·Fumika EndohYoko Ohtsuka
May 22, 2007·Early Human Development·Daniela RicciFabio Mosca
Aug 31, 2006·Pediatric Neurology·Zvonka Rener-PrimecDavid Neubauer
Sep 2, 2018·Neurology·Elena GardellaRikke S Møller
May 25, 2021·Developmental Medicine and Child Neurology·Heather E OlsonGena Heidary
Sep 23, 2021·Journal of Child Neurology·Dylan BrockScott Demarest

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