Abstract
Several studies have reported behavioral and electrophysiological evidence of visual impairment during the active stage of West syndrome. The underlying mechanisms are, however, poorly understood, and little has been reported about the correlation between visual impairment, EEG patterns, and brain lesions. The aim of the study was to assess visual function at the onset of spasm and 2 months thereafter and relate visual findings to brain lesions and EEG features. Twenty-five infants with West syndrome were enrolled and studied with (a) a full clinical assessment including a battery of tests specifically designed to assess visual function, (b) a video-polygraphic study, and (c) brain magnetic resonance imaging (MRI). Besides brain neuroimaging and EEG comparison with visual function, an intra-EEG analysis was performed to investigate the possible relation of EEG patterns to fluctuating visual behavior (fixation and following). Twenty-two children had at least one abnormal result on one or more of the tests assessing visual function at T0. Visual impairment at the spasm onset was related to the sleep disorganization rather than to the hypsarrhythmic pattern in awake EEG. After 2 months, both EEG features become significantly linke...Continue Reading
References
Sep 1, 1979·Annals of Neurology·P KellawayT Zion
Jan 1, 1990·Epilepsia·E P Vining
Oct 1, 1989·Child Development·J ColomboF D Horowitz
Oct 1, 1988·Child Development·M MossF D Horowitz
Jan 1, 1987·Brain & Development·D Wenzel
Aug 1, 1986·Behavioural Brain Research·J MushinG B Arden
May 1, 1993·Developmental Medicine and Child Neurology·F GuzzettaM Isaya Crinó
Jul 1, 1994·Epilepsia·K IinumaT Saito
Jul 1, 1993·Epilepsia·I JambaquéP Syrota
Jul 1, 1993·Epilepsia·F VigevanoL Milani
Jul 1, 1993·Epilepsia·O DulacI Jambaqué
Jan 1, 1997·Neurology·U KramerM A Mikati
Jan 26, 1999·Pediatrics·E MercuriL Dubowitz
Oct 9, 2001·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·A GuzzettaE Mercuri
Nov 10, 2001·Brain & Development·A Okumura, K Watanabe
Jul 10, 2002·Epilepsia·Francesco GuzzettaAndrea Guzzetta
Dec 31, 2002·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Brian P BrooksSteven M Archer
Dec 1, 1955·Archives of Disease in Childhood·R S ILLINGWORTH
Citations
Oct 27, 2007·Neuropsychology Review·William S MacAllister, Sarah G Schaffer
Nov 16, 2006·Epilepsia·Franco Guzzetta
Jan 14, 2010·Epilepsia·Paola De RoseEugenio Mercuri
Dec 5, 2006·Archives of Disease in Childhood. Fetal and Neonatal Edition·Daniela RicciEugenio Mercuri
Oct 23, 2009·CNS Drugs·John M WildEmilio Perucca
Dec 8, 2007·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Francesco GuzzettaFrancesca Tinelli
Jun 9, 2007·Brain & Development·Fumika EndohYoko Ohtsuka
May 22, 2007·Early Human Development·Daniela RicciFabio Mosca
Jul 25, 2007·Epilepsia·Michael SiniatchkinUlrich Stephani
Aug 31, 2006·Pediatric Neurology·Zvonka Rener-PrimecDavid Neubauer
Feb 17, 2006·Brain & Development·G BaranelloF Guzzetta
Apr 4, 2008·Vision Research·F TinelliG Cioni
Jul 18, 2019·Epilepsia·Scott T DemarestTim A Benke
Sep 2, 2018·Neurology·Elena GardellaRikke S Møller
May 25, 2021·Developmental Medicine and Child Neurology·Heather E OlsonGena Heidary
Jul 3, 2021·Genes·Roberta OnesimoGiuseppe Zampino
Sep 23, 2021·Journal of Child Neurology·Dylan BrockScott Demarest