Visual inspection with acetic acid as a feasible screening test for cervical neoplasia in Iran

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
F GhaemmaghamiR Moghimi

Abstract

The aim of this study was to estimate the sensitivity and specificity of visual inspection of the uterine cervix with acetic acid (VIA) as a screening test for cervical carcinoma and its precursors. One thousand and two hundred eligible women were screened by VIA and Papanicolaou smear. Those positive on one or both of these screening tests (n = 308) or those who had clinically suspicious lesions, even if the tests were negative [25% of remainders (n = 290)], were referred for colposcopy. Three hundred and fifty five of 598 women at colposcopy underwent biopsies or endocervical curettage. Those with cervical intraepithelial neoplasia I (CIN I) or worse lesions, diagnosed by histology, were considered true positive. VIA was positive in 191 women (16.1%). In 175 true-positive cases, VIA detected 130 cases, yielding a sensitivity of 74.3% and a specificity of 94%. By considering atypical squamous cell of undetermined significance or worse lesions on Papanicolaou smear as referring threshold for colposcopy, the sensitivity and specificity of cytology were 72 and 90.2%, respectively. In conclusion, the sensitivity and specificity of VIA is high and comparable with that of cytology. Hence, VIA can be undertaken as a feasible method o...Continue Reading

References

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Citations

Feb 7, 2016·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Reem A MustafaHolger J Schünemann
Jul 8, 2008·Taiwanese Journal of Obstetrics & Gynecology·Zip-Pon ChenTim-Tso Lee
Jul 29, 2011·The Journal of Obstetrics and Gynaecology Research·Malihe HasanzadehFariba Samadi
Oct 7, 2016·Annals of Saudi Medicine·Hazem Mahmoud Al-MandeelRomina Brignardello-Petersen
Jul 4, 2008·Journal of Lower Genital Tract Disease·Amr H El-ShalakanyZeinab Sehab El Din
Feb 18, 2011·Cancer Nursing·Melek Ardahan, Ayla Bayik Temel
Feb 16, 2007·European Journal of Gastroenterology & Hepatology·José L Vázquez-IglesiasMaría J Lorenzo
Jul 19, 2017·Journal of Global Oncology·Ramadhani S ChambusoRui M Medeiros
Feb 4, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Nahid KhodakaramiMohamad Esmaeil Akbari
Nov 26, 2008·Reproductive Health Matters·Tahera AhmedJebunnessa Rahman
Jun 24, 2017·Journal of Gynecology Obstetrics and Human Reproduction·A DumontH-J Philippe

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