Visual mismatch negativity highlights abnormal pre-attentive visual processing in mild cognitive impairment and Alzheimer's disease

Neuropsychologia
Andrea TalesStuart Butler

Abstract

Alzheimer's disease (AD) and mild cognitive impairment (MCI) are traditionally characterised in relation to abnormalities in higher-level brain function, particularly memory. However, in the study presented here we report significant abnormality in pre-attentive visual processing in both MCI and AD compared to healthy ageing. The functional integrity of the automatic change detection system was determined by measuring the visual mismatch negativity (vMMN) component of the N2 visual event-related potential (ERP) in 8 individuals with amnestic MCI, 10 individuals with AD and 10 healthy older adult controls. Compared to healthy ageing, both the MCI and AD groups displayed a significant abnormally increased vMMN over the 140-250 ms measurement epoch although such effects were not apparent over the later 250-400 ms epoch. These novel findings support the view that deficits in brain function in both AD and MCI are not exclusively high-level and indeed that abnormal output from 'low level' or pre-attentive processes (as evinced by the abnormal vMMN) is likely to contribute to the high-level processing deficits so characteristic of these clinical disorders.

References

Jun 1, 1992·Brain : a Journal of Neurology·R ParasuramanC L Grady
Oct 1, 1995·Neuropathology and Applied Neurobiology·G Leuba, K Saini
Oct 29, 1997·Psychopharmacology·P RiekkinenP Riekkine
Jan 13, 1998·Vision Research·L Nobili, W G Sannita
Mar 27, 1999·Brain : a Journal of Neurology·R J Perry, J R Hodges
Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Dec 22, 1999·Neuroreport·A TalesS Butler
Sep 15, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M J MentisS I Rapoport
Dec 26, 2001·Archives of Neurology·R C PetersenB Winblad
Jan 5, 2002·Proceedings of the National Academy of Sciences of the United States of America·Reisa SperlingMarilyn Albert
Sep 5, 2002·Neuropsychologia·Andrea TalesRobert J Snowden
Apr 12, 2003·Brain : a Journal of Neurology·Voyko Kavcic, Charles J Duffy
Jul 11, 2003·Biological Psychology·P Pazo-AlvarezE Amenedo
Aug 9, 2003·Nature Reviews. Drug Discovery·Ronald C Petersen
Dec 24, 2003·Brain : a Journal of Neurology·U P MosimannR M Müri
Feb 20, 2004·Journal of Clinical and Experimental Neuropsychology·Salina J van RhijnAbass Alavi
Apr 14, 2004·The European Journal of Neuroscience·P Pazo-AlvarezF Cadaveira
Apr 20, 2004·Neuroreport·Charlotte StaggStuart Butler
Apr 20, 2004·Neuroreport·Stefan Berti, Erich Schröger
Jun 16, 2004·Neuroscience Letters·István CziglerLívia G Pató
Aug 25, 2004·Journal of Internal Medicine·L BäckmanB J Small
Apr 5, 2005·Neurocase·Andrea TalesGordon Wilcock
Apr 7, 2005·Journal of Cognitive Neuroscience·István WinklerLászlo Balázs
Aug 27, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Toshihiko MaekawaShozo Tobimatsu
Jan 13, 2006·Archives of Neurology·William R MarkesberyDavid R Wekstein
Apr 8, 2006·Neuroscience Letters·István CziglerIstván Winkler
May 10, 2006·Archives of Neurology·Ronald C PetersenEmre Kokmen
May 10, 2006·Archives of Neurology·Gregory A JichaRonald C Petersen
Jun 20, 2006·Lancet·Peter Whitehouse, Henry Brodaty
Jun 20, 2006·Journal of Neuropathology and Experimental Neurology·Ann C McKeePhilip A Wolf
Sep 30, 2006·Brain : a Journal of Neurology·Vivek SinghNoor Jehan Kabani

❮ Previous
Next ❯

Citations

Nov 18, 2009·Neuroreport·Andrea TalesStuart Butler
Jan 1, 2012·Expert Opinion on Medical Diagnostics·Vasilios K Kimiskidis, Vasileios T Papaliagkas
Dec 16, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R NäätänenC Ponton
Jul 18, 2015·Behavioural Brain Research·Craig HedgeJonathan C W Brooks
May 14, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jan KremláčekGábor Stefanics
Dec 6, 2011·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Motohiro Kimura
Oct 11, 2012·Neurobiology of Aging·George StothartNina Kazanina
Oct 4, 2014·Frontiers in Human Neuroscience·Gábor StefanicsIstván Czigler
Oct 23, 2018·Current Alzheimer Research·Cassandra MorrisonFrank Knoefel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.