Visual Outcomes of Fractionated Radiotherapy in Optic Nerve Sheath Meningioma: A Retrospective Study

Klinische Monatsblätter für Augenheilkunde
Valeria KheirFrançois-Xavier Borruat

Abstract

Optic nerve sheath meningioma (ONSM) is a rare benign tumour of the optic nerve sheath that can lead to blindness if untreated. Radiotherapy is commonly accepted as being the treatment of choice. We conducted a retrospective monocentric study to assess the effect of radiotherapy on visual outcomes and tumour control in patients with ONSM. The charts of all patients affected by ONSM between 1994 and 2016 were reviewed retrospectively. Inclusion criteria were: having been followed by our department, initial visual acuity (VA) better than no light perception, and stereotactic fractionated radiotherapy. VA (Snellen), colour vision (Ishihara), and visual field mean defect (in dB), as well as ONSM size (on MRI) were compared before and after radiotherapy. Visual function was considered improved if two or more criteria improved, stabilised if none or only one criterion changed, and worsened if two or more criteria worsened. The Wilcoxon signed-rank test was used to assess the effect of radiotherapy (significant if p value < 0.05). VA improved or stabilised in 13/16 patients (81.25%), with median VA improving from 0.1 logMAR (8/10) to 0 logMAR (10/10) (p value = 0.0134). Colour vision improved or stabilised in 11/15 patients (73.33%), ...Continue Reading

Citations

Mar 30, 2021·Journal of Neurological Surgery. Part B, Skull Base·Elena Solli, Roger E Turbin

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