PMID: 11329493May 1, 2001Paper

Visual p3 in female alcoholics

Alcoholism, Clinical and Experimental Research
V R PrabhuH Begleiter

Abstract

The P300 (P3) component of the event related potential has been established as a sensitive risk marker of vulnerability to alcoholism. Most alcoholism studies have focused on men; recent studies indicate that women are equally vulnerable to developing alcoholism. Visual P3 recorded from 31 electrode positions was evaluated in 44 alcoholic and 60 control women, 24-50 years of age. P3 amplitudes and latencies of the two groups were statistically compared using Analysis of Variance; source localization of surface amplitude values from each group were plotted using a low-resolution brain electromagnetic tomography. The results indicated that alcoholic women had significantly smaller P3 amplitudes in the frontal and central regions compared with controls. Source localization showed lowered activation in alcoholic women in right dorso-lateral prefrontal cortex and the ventro-medial fronto-central regions. The results suggest that P3 is an equally sensitive endophenotypic marker of vulnerability to alcoholism in women. The findings are discussed in terms of functional and physiologic significance of the P3 amplitude in alcoholic women and its relationship to drinking behaviors.

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Citations

Apr 14, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Chella KamarajanHenri Begleiter
Apr 14, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Bernice PorjeszHenri Begleiter
May 24, 2003·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·William G IaconoMatt McGue
Oct 19, 2002·Biological Psychology·Bernice PorjeszTheodore Reich
Sep 27, 2003·Psychiatry Research·Rebecca J HoustonVictor M Hesselbrock
Oct 29, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Linda L ChaoMichael W Weiner
Sep 19, 2006·Psychological Medicine·Jonathan Flint, Marcus R Munafò
Nov 30, 2006·The Journal of General Psychology·Natalie A Ceballos
Jan 12, 2007·Journal of Cognitive Neuroscience·Jürgen GallinatGeorg Winterer
Sep 15, 2004·Alcoholism, Clinical and Experimental Research·Kee NamkoongSuk Kyoon An
Jul 25, 2003·Alcoholism, Clinical and Experimental Research·Sudha SureshHenri Begleiter
Nov 23, 2006·Alcoholism, Clinical and Experimental Research·George Fein, Maria Chang
Jul 28, 2010·Alcoholism, Clinical and Experimental Research·Bangalore N RoopeshBernice Porjesz
Mar 1, 2011·Alcoholism, Clinical and Experimental Research·George Fein, Colin Andrew
Sep 22, 2009·Alcoholism, Clinical and Experimental Research·Bangalore N RoopeshBernice Porjesz
Jun 1, 2005·Biological Psychology·Chella KamarajanHenri Begleiter
Sep 22, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Chella KamarajanBernice Porjesz

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