Visual pathway neurodegeneration winged by mitochondrial dysfunction

Annals of Clinical and Translational Neurology
Axel PetzoldJack van Horssen

Abstract

To test for structural and functional contribution of mitochondrial dysfunction to neurodegeneration in multiple sclerosis (MS). A visual pathway model void of MS lesions was chosen in order to exclude neurodegeneration secondary to lesion related axonotmesis. A single-centre cohort study (230 MS patients, 63 controls). Spectral domain optical coherence tomography of the retina, 3T magnetic resonance imaging of the brain, spectrophotometric assessment of serum lactate levels. Postmortem immunohistochemistry. The visual pathway was void of MS lesions in 31 patients and 31 age-matched controls. Serum lactate was higher in MS compared to controls (P = 0.029). High serum lactate was structurally related to atrophy of the retinal nerve fiber layer at the optic disc (P = 0.041), macula (P = 0.025), and the macular ganglion cell complex (P = 0.041). High serum lactate was functionally related to poor color vision (P < 0.01), Expanded Disability Status Scale score (R = 0.37, P = 0.041), Guy's Neurological disability score (R = 0.38, P = 0.037), MS walking scale (R = 0.50, P = 0.009), upper limb motor function (R = 0.53, P = 0.002). Immunohistochemistry demonstrated increased astrocytic expression of a key lactate generating enzyme in M...Continue Reading

References

Oct 1, 1990·Brain : a Journal of Neurology·G T Plant, V H Perry
Oct 1, 1967·The British Journal of Ophthalmology·B Ashworth
Jan 29, 1998·The New England Journal of Medicine·B D TrappL Bö
Jul 8, 2000·American Journal of Clinical Pathology·J D ArtissB Zak
Mar 14, 2002·Journal of Magnetic Resonance Imaging : JMRI·Declan T ChardDavid H Miller
Feb 20, 2009·Brain : a Journal of Neurology·Panitha JindahraGordon T Plant
Jan 22, 2011·Brain : a Journal of Neurology·Shiv SaidhaPeter A Calabresi
May 21, 2011·Brain : a Journal of Neurology·A U BrandtS Schippling
Jul 28, 2011·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Fiona E CostelloRandy Kardon
Jan 26, 2012·Aviation, Space, and Environmental Medicine·Marisa Rodriguez-CarmonaJohn L Barbur
Feb 15, 2012·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·John L Barbur, Evgenia Konstantakopoulou
Sep 1, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Hanna ZimmermannAlexander U Brandt
Sep 7, 2012·PloS One·Anja MählerFriedemann Paul
Sep 26, 2012·Nature Reviews. Neurology·Hans LassmannDon Mahad
Feb 26, 2013·Clinical & Experimental Ophthalmology·Alfredo A SadunValerio Carelli
May 25, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Timm OberwahrenbrockFriedemann Paul
Aug 21, 2013·CNS Drugs·Amir-Hadi MaghziEmmanuelle Waubant
Oct 9, 2013·Journal of Neurology·Lisanne BalkAxel Petzold
Oct 12, 2013·Annals of Neurology·Iñigo GabilondoPablo Villoslada
Dec 29, 2013·Trends in Molecular Medicine·Maarten E WitteJack van Horssen
Jan 10, 2014·Multiple Sclerosis : Clinical and Laboratory Research·L J BalkA Petzold
Jan 30, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·L J BalkA Petzold
Mar 19, 2014·Nature Reviews. Neurology·Manuel A FrieseLars Fugger
Apr 15, 2014·Biochimica Et Biophysica Acta·Angela M AmoriniBarbara Tavazzi
Jun 21, 2014·Multiple Sclerosis : Clinical and Laboratory Research·S SchipplingA Petzold
Jul 9, 2014·Nature Reviews. Neurology·Axel PetzoldGordon T Plant
Aug 19, 2014·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Fiona E Costello
Oct 31, 2014·Annals of Clinical and Translational Neurology·Joungil ChoiJames W Russell

❮ Previous
Next ❯

Citations

Dec 8, 2015·Acta Neuropathologica Communications·Philip G NijlandJack van Horssen
Apr 17, 2018·International Journal of Molecular Sciences·Alexandre ValléeJean-Noël Vallée
Aug 1, 2019·Brain : a Journal of Neurology·Willemien A de Vries-KnoppertAxel Petzold
Apr 14, 2019·Antioxidants·Giacomo LazzarinoPasquale Bilotta
Dec 29, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Sharon Y L ChuaUNKNOWN UK Biobank Eye, Vision Consortium
Apr 4, 2021·Life·Vanja Tepavčević

❮ Previous
Next ❯

Software Mentioned

SIENAX
HEYEX
Heidelberg Spectralis
FMRIB Software Library [ FSL
SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.