Visual perception in prediagnostic and early stage Huntington's disease.

Journal of the International Neuropsychological Society : JINS
Brian F O'DonnellTatiana Foroud

Abstract

Disturbances of visual perception frequently accompany neurodegenerative disorders but have been little studied in Huntington's disease (HD) gene carriers. We used psychophysical tests to assess visual perception among individuals in the prediagnostic and early stages of HD. The sample comprised four groups, which included 201 nongene carriers (NG), 32 prediagnostic gene carriers with minimal neurological abnormalities (PD1); 20 prediagnostic gene carriers with moderate neurological abnormalities (PD2), and 36 gene carriers with diagnosed HD. Contrast sensitivity for stationary and moving sinusoidal gratings, and tests of form and motion discrimination, were used to probe different visual pathways. Patients with HD showed impaired contrast sensitivity for moving gratings. For one of the three contrast sensitivity tests, the prediagnostic gene carriers with greater neurological abnormality (PD2) also had impaired performance as compared with NG. These findings suggest that early stage HD disrupts visual functions associated with the magnocellular pathway. However, these changes are only observed in individuals diagnosed with HD or who are in the more symptomatic stages of prediagnostic HD.

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Citations

Oct 20, 2018·Frontiers in Behavioral Neuroscience·Tuukka O PiiponniemiMaksym V Kopanitsa
Feb 6, 2016·Vestnik oftalmologii·S N SvetozarskiyI G Smetankin
Apr 30, 2019·Journal of Huntington's Disease·Tamara MatheisLisa Muratori
Apr 2, 2019·Journal of Huntington's Disease·Amit DhallaClaire V Hutchinson
Oct 6, 2020·Neuro-ophthalmology·Ali G HamedaniPedro Gonzalez-Alegre
May 25, 2018·Behavioural Brain Research·Emma M CoppenRaymund A C Roos

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