Visual performance using a retinal prosthesis in three subjects with retinitis pigmentosa

American Journal of Ophthalmology
Douglas YanaiMark S Humayun

Abstract

To assess visual task performance in three blind subjects implanted with epiretinal prostheses. Prospective, investigational device exemption trial. Three subjects with light perception or no light perception vision were enrolled at a single center. All subjects had retinitis pigmentosa (RP). Main inclusion criteria: light perception or worse vision in one eye and some visual experience as an adult before blindness. Main exclusion criteria included other ophthalmic problems. A prototype retinal prosthesis was implanted in the eye with worse light sensitivity. The prosthesis had 4 x 4 array of platinum electrodes tacked to the epiretinal surface. The prosthesis was wirelessly controlled by a computer or by a head-worn video camera. Visual function testing was performed in single masked or double masked fashion. Scores from the visual task were compared to chance to determine statistical significance. The subjects performed significantly better than chance in 83% of the tests. Using the video camera, subjects scored as follows on simple visual tasks: locate and count objects (77% to 100%), differentiate three objects (63% to 73%), determine the orientation of a capital L (50% to 77%), and differentiate four directions of a moving...Continue Reading

References

Apr 21, 1999·The British Journal of Ophthalmology·N H Chong, A C Bird
Jul 9, 1999·Vision Research·Mark S HumayunS Suzuki
Feb 9, 2002·Science·Eberhart Zrenner
Aug 6, 2002·Survey of Ophthalmology·Eyal MargalitMark S Humayun
Aug 2, 2003·Progress in Retinal and Eye Research·Robert E MarcE Strettoi
Aug 26, 2003·Nature Neuroscience·Ione FineDonald I A MacLeod
Nov 18, 2003·Artificial Organs·Claude VeraartJean Delbeke
Nov 26, 2003·Investigative Ophthalmology & Visual Science·Joseph F RizzoDoug Shire
Nov 26, 2003·Investigative Ophthalmology & Visual Science·Joseph F RizzoDoug Shire
Apr 14, 2004·Archives of Ophthalmology·David S FriedmanEye Diseases Prevalence Research Group
Jul 12, 2005·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Manjunatha MahadevappaMark S Humayun

Citations

Mar 29, 2008·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·H Gerding
Aug 19, 2008·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Dimiter R BertschingerJoel Salzmann
Apr 6, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Gernot RoesslerEPIRET Group
Aug 24, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Thomas LaubeNorbert Bornfeld
Dec 26, 2009·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Toshihiko MatsuoKenichi Takarabe
Mar 27, 2013·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs· AlamusiTetsuya Uchida
Sep 27, 2012·Japanese Journal of Ophthalmology·Thomas FitzGibbon, S F Taylor
Aug 3, 2007·Nature Clinical Practice. Neurology·Richard A Normann
May 22, 2009·Journal of Neural Engineering·Hossein AmeriJames D Weiland
May 20, 2011·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Joseph F Rizzo
Nov 5, 2010·Proceedings. Biological Sciences·Eberhart ZrennerR Wilke
Aug 4, 2011·Artificial Organs·Yanyu LuXinyu Chai
Mar 21, 2012·Artificial Organs·Hossein Mahvash MohammadiMohamad Sawan
Apr 24, 2008·Annual Review of Biomedical Engineering·Gislin Dagnelie
Mar 11, 2011·Journal of Neurophysiology·Chris SekirnjakE J Chichilnisky
Feb 5, 2011·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Mario MatthaeiGisbert Richard
Apr 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chris SekirnjakE J Chichilnisky
Feb 8, 2014·Biomedical Engineering Online·Florian WaschkowskiGernot Roessler
Nov 5, 2010·Journal of Ophthalmology·Maria A Musarella, Ian M Macdonald
Dec 3, 2014·Medical Engineering & Physics·Erich W SchmidR Wilke
Apr 6, 2011·Visual Neuroscience·Eyal MargalitWallace B Thoreson
Mar 1, 2013·The Journal of Experimental Biology·Douglas J Blackiston, Michael Levin
Feb 9, 2016·Ophthalmic Genetics·Aleksandra V Rachitskaya, Alex Yuan
Jan 17, 2012·Ophthalmology·Mark S HumayunArgus II Study Group
Jan 21, 2012·Magnetic Resonance Imaging·James D WeilandFrank G Shellock
Sep 20, 2011·Biomedical Signal Processing and Control·Shawn KellyJoseph F Rizzo
May 6, 2009·Current Opinion in Genetics & Development·Edwin M Stone
Aug 16, 2008·The European Journal of Neuroscience·Timothy L Siu, John W Morley
May 18, 2011·Clinical & Experimental Ophthalmology·Jong Min Ong, Lyndon da Cruz
Jun 18, 2011·The Journal of Comparative Neurology·Bryan W JonesRobert E Marc
Sep 17, 2013·Artificial Organs·Jie HuYinghong Peng
Nov 7, 2014·IEEE Transactions on Bio-medical Engineering·Ronald T LeungRobert K Shepherd
Apr 9, 2014·IEEE Transactions on Bio-medical Engineering·James D Weiland, Mark S Humayun
May 1, 2009·IEEE Transactions on Bio-medical Engineering·Douglas B ShireJoseph F Rizzo
Dec 1, 2008·IEEE Transactions on Biomedical Circuits and Systems·V SinghG Lazzi
Aug 24, 2011·IEEE Transactions on Bio-medical Engineering·Shawn KellyJoseph F Rizzo
Oct 20, 2011·IEEE Transactions on Bio-medical Engineering·Nicholas L OpieDavid B Grayden
Sep 24, 2015·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Alex E HadjinicolaouMichael R Ibbotson
Aug 28, 2015·Journal of Neuroengineering and Rehabilitation·Xun CaoXinyu Chai
Jul 31, 2012·Neuron·Aleksandra PolosukhinaRichard Kramer
Sep 21, 2013·Translational Vision Science & Technology·Amy NauChristopher Fisher
Jan 3, 2014·Biomaterials·Kumaravelu GanesanSteven Prawer
Nov 4, 2011·Ophthalmology·James D WeilandMark S Humayun
Mar 11, 2009·Vision Research·Y T WongGregg J Suaning
Jul 18, 2009·Vision Research·Spencer C ChenNigel H Lovell
Jun 9, 2009·Vision Research·Spencer C ChenNigel H Lovell
Aug 28, 2007·Vision Research·Frédéric Gaillard, Yves Sauvé
Dec 3, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Douglas J BlackistonMichael Levin
May 31, 2016·Progress in Retinal and Eye Research·Lan YueMark S Humayun
Aug 8, 2009·Progress in Brain Research·Gerald J ChaderMark S Humayun
Sep 25, 2016·Ophthalmology·Mark S HumayunGislin Dagnelie
Dec 22, 2017·Artificial Organs·Ying ZhaoXiaoqi Lv
Jul 20, 2018·Journal of Neural Engineering·A Soto-BrecedaMichael R Ibbotson
Sep 2, 2009·Journal of Neural Engineering·B C BasingerJames D Weiland
Feb 16, 2012·Journal of Neural Engineering·Ling WangEnric Claverol-Tinturé
Apr 19, 2013·Journal of Neural Engineering·Changsi CaiS I Fried
Jul 1, 2013·Asia-Pacific Journal of Ophthalmology·Alan Y Chow
Dec 7, 2013·Expert Review of Medical Devices·H Christiaan Stronks, Gislin Dagnelie
Nov 26, 2019·Advanced Healthcare Materials·Annarita Cutrone, Silvestro Micera
Jan 16, 2010·Journal of Neural Engineering·N ParikhJames D Weiland
Apr 30, 2017·Journal of Neural Engineering·S B GoncalvesJ H Correia
May 22, 2009·Journal of Neural Engineering·S C ChenNigel H Lovell
Jun 27, 2020·Journal of Neural Engineering·Dorsa Haji GhaffariJames D Weiland
Aug 17, 2016·Journal of Neural Engineering·Sohmyung HaGert Cauwenberghs
Aug 6, 2020·Healthcare Technology Letters·Rachael Theresa RichardsonJames B Fallon
Apr 4, 2013·Journal of Neural Engineering·Jerel K Mueller, Warren M Grill
Mar 3, 2017·Nature Materials·José Fernando Maya-VetencourtFabio Benfenati
Mar 2, 2013·Journal of Neural Engineering·N ParikhJames D Weiland
Aug 7, 2013·The International Journal of Artificial Organs·Pontus LinderholmS Picaud
Jun 27, 2019·Scientific Reports·Michael BeyelerIone Fine
Jan 31, 2017·Clinical & Experimental Ophthalmology·Thomas FitzGibbon
Nov 17, 2020·Frontiers in Bioengineering and Biotechnology·José Fernando Maya-VetencourtFabio Benfenati
Feb 27, 2021·Frontiers in Human Neuroscience·Maurice PtitoDaniel-Robert Chebat

Related Concepts

Implantable Stimulation Electrodes
Retina
Cone-Rod Dystrophy 2
Signal Processing, Digital
Critical Incident Technique
Video Recording
Visual Impairment
Visual Perception
Prostheses and Implants
Prosthesis Implantation

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

© 2021 Meta ULC. All rights reserved