Visual processing as a potential endophenotype in youths with attention-deficit/hyperactivity disorder: A sibling study design using the counting Stroop functional MRI

Human Brain Mapping
Li-Ying FanTai-Li Chou

Abstract

Deficits in inhibitory control and visual processing are common in youths with attention-deficit/hyperactivity disorder (ADHD), but little is known about endophenotypes for unaffected siblings of youths with ADHD. This study aimed to investigate the potential endophenotypes of brain activation and performance in inhibitory control and visual processing among ADHD probands, their unaffected siblings, and neurotypical youths. We assessed 27 ADHD probands, 27 unaffected siblings, and 27 age-, gender-, and IQ-matched neurotypical youths using the counting Stroop functional magnetic resonance imaging and two tasks of the Cambridge Neuropsychological Test Automated Battery (CANTAB): rapid visual information processing (RVP) for inhibitory control and spatial span (SSP) for visual processing. ADHD probands showed greater activation than their unaffected siblings and neurotypical youths in the right inferior frontal gyrus (IFG) and anterior cingulate cortex. Increased activation in the right IFG was positively correlated with the mean latency of the RVP in ADHD probands. Moreover, ADHD probands and their unaffected siblings showed less activation in the left superior parietal lobule (SPL) than neurotypical youths. Increased activation ...Continue Reading

References

Aug 31, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·O Josephs, R N Henson
Apr 2, 2003·The American Journal of Psychiatry·Irving I Gottesman, Todd D Gould
Apr 13, 2004·Journal of the American Academy of Child and Adolescent Psychiatry·Sarah DurstonHerman van Engeland
Jun 14, 2005·Biological Psychiatry·Stephen V FaraonePamela Sklar
Jun 14, 2005·Biological Psychiatry·Alysa E DoyleStephen V Faraone
Oct 18, 2007·Expert Review of Neurotherapeutics·Yannis PaloyelisPhilip Asherson
Jan 21, 2010·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Susan Shur-Fen Gau, Chi-Yung Shang
Feb 10, 2010·Molecular Psychiatry·K S Kendler, M C Neale
Apr 3, 2013·Expert Review of Neurotherapeutics·Glaucia Chiyoko Akutagava-MartinsMara Helena Hutz
Dec 17, 2014·Current Opinion in Neurobiology·Lisa A Friedman, Judith L Rapoport
Sep 28, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Tai-Li ChouSusan Shur-Fen Gau

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Citations

May 1, 2020·Psychological Medicine·Guan-Jye SengSusan Shur-Fen Gau
Feb 6, 2019·Frontiers in Behavioral Neuroscience·George SavulichBarbara J Sahakian
Oct 22, 2020·Journal of Developmental and Behavioral Pediatrics : JDBP·Mao-Hsiu HuaYu-Te Wu
Feb 24, 2021·Journal of Psychiatric Research·Wei-Lieh HuangSusan Shur-Fen Gau

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