Visual prognosis of massive submacular hemorrhage in polypoidal choroidal vasculopathy with or without combination treatment

Journal of the Chinese Medical Association : JCMA
Tai-Chi LinShih-Jen Chen

Abstract

Submacular hemorrhage associated with polypoidal choroidal vasculopathy (PCV) may cause severe visual loss. The purpose of this study is to report the visual prognosis of massive submacular hemorrhage in patients with PCV. Twenty patients with PCV and submacular hemorrhage who received either subretinal tissue plasminogen activator (TPA) with vitrectomy or intravitreal injection of TPA and gas to achieve pneumatic displacement of the hemorrhage were enrolled. Additionally, combination treatment with either photodynamic therapy (PDT) or intravitreal injection of vascular endothelial growth factor inhibitors (anti-VEGF) was performed to treat the underlying PCV. Five patients received subretinal TPA with vitrectomy and 15 patients received intravitreal injection of TPA and gas to remove or displace the submacular hemorrhage. Combination treatment with PDT and intravitreal anti-VEGF was performed in three patients and intravitreal anti-VEGF injection alone in 13 patients. The mean logarithm of the minimal angle of resolution converted from the best corrected visual acuity (BCVA) were improved at 3 months, 6 months, and 12 months. Better initial BCVA, smaller size of submacular hemorrhage and younger age were statistically signific...Continue Reading

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Citations

Oct 25, 2017·Asia-Pacific Journal of Ophthalmology·Paradee KunavisarutAniki Rothova
Jan 1, 2020·International Journal of Retina and Vitreous·Giamberto CasiniMarco Nardi
Mar 6, 2019·Therapeutic Advances in Ophthalmology·Atul KumarRohan Chawla

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