Aug 28, 2009

Visual receptive field structure of cortical inhibitory neurons revealed by two-photon imaging guided recording

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Bao-Hua LiuHuizhong W Tao

Abstract

Synaptic inhibition plays an important role in shaping receptive field (RF) properties in the visual cortex. However, the underlying mechanisms remain not well understood, partly because of difficulties in systematically studying functional properties of cortical inhibitory neurons in vivo. Here, we established two-photon imaging guided cell-attached recordings from genetically labeled inhibitory neurons and nearby "shadowed" excitatory neurons in the primary visual cortex of adult mice. Our results revealed that in layer 2/3, the majority of excitatory neurons exhibited both On and Off spike subfields, with their spatial arrangement varying from being completely segregated to overlapped. In contrast, most layer 4 excitatory neurons exhibited only one discernable subfield. Interestingly, no RF structure with significantly segregated On and Off subfields was observed for layer 2/3 inhibitory neurons of either the fast-spike or regular-spike type. They predominantly possessed overlapped On and Off subfields with a significantly larger size than the excitatory neurons and exhibited much weaker orientation tuning. These results from the mouse visual cortex suggest that different from the push-pull model proposed for simple cells, l...Continue Reading

  • References55
  • Citations80

Mentioned in this Paper

Optic Tract Structure
Space Perception
Pattern Recognition, Visual
Gad1 protein, human
Neural Inhibition
Neurons
Glutamate Decarboxylase
Visual Fields
Structure of Cortex of Kidney
Voltage-Clamp Techniques

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