PMID: 6973117Apr 1, 1981Paper

Visual results of a long-term trial of a low-arginine diet in gyrate atrophy of choroid and retina

Ophthalmology
M I Kaiser-KupferS W Brusilow

Abstract

Visual function has been serially assessed in two gyrate atrophy patients who have had long-term reduction of plasma ornithine concentrations by a low-arginine diet. One patient demonstrated subjective and objective improvement after 15 months of treatment. In addition to improvements in dark adaptation thresholds, enlargement of visual fields, and a more normal electroretinogram, there was marked improvement in cone function as measured by color vision. There has been no change noted in the second patient. These results suggest that reduction of plasma ornithine may be beneficial in gyrate atrophy patients and that the high ornithine concentrations characteristic of this disorder play some role in the pathophysiology.

References

Feb 1, 1978·American Journal of Ophthalmology·M I Kaiser-KupferL A Del Valle
Feb 1, 1980·American Journal of Ophthalmology·M I Kaiser-KupferA J Bron

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Citations

Sep 17, 2009·Journal of Inherited Metabolic Disease·C P BarnettA Schulze
May 20, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·K OjalaK K Takki
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·T WangD Valle
Mar 8, 2005·The Tohoku Journal of Experimental Medicine·Yumiko OhkuboHajime Togari
Jan 17, 2014·Documenta Ophthalmologica. Advances in Ophthalmology·Satoshi KatagiriHiroshi Tsuneoka
May 25, 2004·Expert Opinion on Biological Therapy·Thomas G Jensen
May 1, 1982·Survey of Ophthalmology·J François

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