PMID: 9191106Jun 1, 1997Paper

Visual sensitivities of nur77 (NGFI-B) and zif268 (NGFI-A) induction in the suprachiasmatic nucleus are dissociated from c-fos induction and behavioral phase-shifting responses

Brain Research. Molecular Brain Research
J T LinJ S Takahashi

Abstract

Mammalian circadian rhythms are regulated by a pacemaker in the suprachiasmatic nucleus of the hypothalamus. Recent work from several laboratories has shown that light induces the IEGs, c-fos and jun-B, in the rodent suprachiasmatic nucleus. In hamsters, there is a strong correlation between circadian entrainment and the induction of c-fos and jun-B in the suprachiasmatic nucleus by light. Previous work has shown that the IEGs, nur77 and zif268, both of which encode transcription factors, are also light-inducible in the rat suprachiasmatic nucleus [Rusak, B., McNaughton, L., Robertson, H.A. and Hunt, S.P., Circadian variation in photic regulation of IEG mRNAs in rat suprachiasmatic nucleus cells, Mol. Brain Res., 14 (1992) 124-130.; Sutin, E.L. and Kilduff, T.S., Circadian and light-induced expression of IEG mRNAs in the rat suprachiasmatic nucleus, Mol. Brain Res., 15 (1992) 281-290.]. To characterize the photic-regulation of these genes in the suprachiasmatic nucleus of golden hamsters, we used in situ hybridization to measure nur77 and zif268 mRNA levels with 33P-labeled complementary RNA probes. 5-min monochromatic light pulses at CT19 induced a dramatic increase in both nur77 and zif268 mRNA levels. Peak mRNA levels occurr...Continue Reading

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Citations

Jun 9, 2000·Annual Review of Neuroscience·D P King, J S Takahashi
Nov 21, 2007·BMC Neuroscience·Veronica M PorterfieldEric M Mintz
Jan 22, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Federico TinarelliValter Tucci
Mar 11, 2004·Journal of Neurochemistry·Pascal E D Lachance, Avi Chaudhuri
Aug 17, 2005·The European Journal of Neuroscience·Gastón A PizzioDiego A Golombek
Jul 26, 2007·The European Journal of Neuroscience·Boyoung LeeKarl Obrietan
Sep 3, 2013·Cell·Aarti JagannathStuart N Peirson
Aug 26, 1998·Journal of Biological Rhythms·T S KilduffH C Heller
Jun 28, 2003·Journal of Biological Rhythms·Johanna H Meijer, William J Schwartz
Jul 31, 2007·Journal of Biological Rhythms·Jennifer A EvansMichael R Gorman
Nov 16, 2017·Journal of Molecular Neuroscience : MN·Casper Schwartz RiedelJan Fahrenkrug
Nov 21, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J M FustinD G Hazlerigg
May 13, 1999·Journal of Neurogenetics·J C Hall

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