PMID: 11926387Apr 3, 2002Paper

Visualisation and assessment of the protein synthesis rate of lung cancer using carbon-11 tyrosine and positron emission tomography

European Journal of Nuclear Medicine and Molecular Imaging
Remge PietermanHarry J M Groen

Abstract

This study evaluated the potential role of L-(1-(11)C)-tyrosine positron emission tomography (TYR PET) for visualisation and quantification of protein metabolism in lung cancer. Dynamic TYR PET scans of the thorax were performed in 17 patients with lung cancer. Protein synthesis rate (PSR in micromol/min x l) and standardised uptake value (SUV, corrected for body measurements) of tumour tissue and contralateral normal tissue were calculated before and after chemotherapy or radiotherapy. All tumours [11 non-small cell lung carcinomas (NSCLCs), five small cell lung carcinomas (SCLCs), and one pleural mesothelioma] were visualised as a hot spot. The median PSR in tumour tissue was higher than that in corresponding contralateral normal lung tissue before [1.88 micromol/min x l (range 1.10-3.42) vs 0.40 micromol/min x l (range 0.12-0.86); P=0.003] and after treatment [1.33 micromol/min x l (range 0.45-2.21) vs 0.28 micromol/min x l (range 0.18-0.51); P<0.02]. In contrast to PSR of normal lung tissue, PSR of tumour tissue decreased significantly after therapy (P=0.03). Before therapy, no significant difference in PSR between NSCLCs and SCLCs was observed, but after therapy the PSR differed significantly between the subgroups [1.69 mi...Continue Reading

Citations

Oct 12, 2010·Revue de pneumologie clinique·F VayletH Foehrenbach
Oct 4, 2005·International Journal of Radiation Oncology, Biology, Physics·Roel J H M SteenbakkersCoen R N Rasch
Apr 29, 2015·Nature Reviews. Clinical Oncology·Willem GrootjansJohan Bussink
Apr 20, 2010·Expert Review of Anticancer Therapy·Cynthia AristeiRoberto Tarducci
Nov 17, 2011·Physics in Medicine and Biology·D BroggioD Franck
Jan 1, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Pierre DecazesKhaldoun Kerrou
Dec 1, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Tao Chan

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