Visualization and prediction of porosity in roller compacted ribbons with near-infrared chemical imaging (NIR-CI)

Journal of Pharmaceutical and Biomedical Analysis
M KhorasaniJukka Rantanen

Abstract

The porosity of roller compacted ribbon is recognized as an important critical quality attribute which has a huge impact on the final product quality. The purpose of this study was to investigate the use of near-infrared chemical imaging (NIR-CI) for porosity estimation of ribbons produced at different roll pressures. Two off-line methods were utilized as reference methods. The relatively fast method (oil absorption) was comparable with the more time-consuming mercury intrusion method (R(2)=0.98). Therefore, the oil method was selected as the reference off line method. It was confirmed by both reference methods that ribbons compressed at a higher pressure resulted in a lower mean porosity. Using NIR-CI in combination with multivariate data analysis it was possible to visualize and predict the porosity distribution of the ribbons. This approach is considered important for process monitoring and control of continuously operating roller compaction line.

References

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Citations

Oct 21, 2015·Analytica Chimica Acta·José Manuel AmigoSaioa Elcoroaristizabal
Nov 8, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Morten AllesøPer Holm
Apr 29, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Milad KhorasaniJukka Rantanen
May 11, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Leandro de Moura FrançaAlberto Ferrer
Jun 10, 2016·Journal of Pharmaceutical and Biomedical Analysis·Brigitta NagyGyörgy Marosi
Jul 6, 2016·Pharmaceutical Research·Changquan Calvin Sun
Nov 5, 2016·International Journal of Pharmaceutics·Milad KhorasaniJukka Rantanen
May 16, 2020·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Aleša Dular Vovko, Franc Vrečer

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