Visualization of Diagnostic and Therapeutic Targets in Glioma With Molecular Imaging.

Frontiers in Immunology
Deling LiZhen Cheng

Abstract

Gliomas, particularly high-grade gliomas including glioblastoma (GBM), represent the most common and malignant types of primary brain cancer in adults, and carry a poor prognosis. GBM has been classified into distinct subgroups over the years based on cellular morphology, clinical characteristics, biomarkers, and neuroimaging findings. Based on these classifications, differences in therapeutic response and patient outcomes have been established. Recently, the identification of complex molecular signatures of GBM has led to the development of diverse targeted therapeutic regimens and translation into multiple clinical trials. Chemical-, peptide-, antibody-, and nanoparticle-based probes have been designed to target specific molecules in gliomas and then be visualized with multimodality molecular imaging (MI) techniques including positron emission tomography (PET), single-photon emission computed tomography (SPECT), near-infrared fluorescence (NIRF), bioluminescence imaging (BLI), and magnetic resonance imaging (MRI). Thus, multiple molecules of interest can now be noninvasively imaged to guide targeted therapies with a potential survival benefit. Here, we review developments in molecular-targeted diagnosis and therapy in glioma,...Continue Reading

References

May 29, 1996·International Journal of Cancer. Journal International Du Cancer·T MoriyamaM Koono
Jul 2, 2003·Circulation·Dilantha B EllegalaJonathan R Lindner
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amy B HeimbergerKenneth Aldape
Oct 21, 2006·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Andrew R HsuXiaoyuan Chen
Nov 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·H Toni JunTeresa L Burgess
Feb 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tobey J MacDonaldLarry E Kun
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roland UllrichAndreas H Jacobs
Sep 6, 2008·Science·D Williams ParsonsKenneth W Kinzler
Sep 12, 2008·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Kai ChenXiaoyuan Chen
Dec 31, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Teri N KreislHoward A Fine
Feb 21, 2009·The New England Journal of Medicine·Hai YanDarell D Bigner
Aug 13, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Heiko BackesAndreas H Jacobs
Oct 3, 2009·Acta Neuropathologica·David CapperAndreas von Deimling
Nov 19, 2009·Cancer Research·Lonneke A M GravendeelPim J French
Feb 16, 2010·Academic Radiology·Scott C DavisBrian W Pogue
Dec 1, 2005·BioTechniques·Weibo CaiXiaoyuan Chen
May 5, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roger StuppMichael Weller
Jul 10, 2010·The Lancet Oncology·Nanne K KloosterhofMartin J van den Bent
Sep 9, 2010·Neoplasia : an International Journal for Oncology Research·Kimmo J HatanpaaAmyn A Habib
Oct 16, 2010·Cancer Letters·Manmeet S AhluwaliaCandece L Gladson
Feb 1, 2011·Analytical Biochemistry·Limin ZhangAlnawaz Rehemtulla
Sep 20, 2011·Journal of Neuro-oncology·Anne ClavreulPhilippe Menei
Dec 7, 2011·Contrast Media & Molecular Imaging·Stefania LanzardoGuido Forni
Feb 1, 2012·The Cancer Journal·Michael WellerWolfgang Wick
Jun 13, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Thomas VielAndreas H Jacobs
Aug 25, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Elaine M JagodaPeter Choyke
Oct 17, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Hiroaki UchidaJoseph C Glorioso
Oct 26, 2012·Neurosurgery·Rheal A TownerJonathan D Wren
Dec 13, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Junghan LeeRita Song
Feb 13, 2013·Journal of Neuropathology and Experimental Neurology·Jens SchittenhelmBence Sipos
Mar 5, 2013·PloS One·Deborah HuveldtPanos Z Anastasiadis

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Methods Mentioned

BETA
PCR
xenograft
xenografts
imaging technique

Clinical Trials Mentioned

NCT03539731
NCT03856099

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