Visualization of drug-nucleic acid interactions at atomic resolution. VIII. Structures of two ethidium/dinucleoside monophosphate crystalline complexes containing ethidium: cytidylyl(3'-5') guanosine

Journal of Biomolecular Structure & Dynamics
S C Jain, H M Sobell

Abstract

This paper describes two complexes containing ethidium and the dinucleoside monophosphate, cytidylyl(3'-5')guanosine (CpG). Both crystals are monoclinic, space group P2l, with unit cell dimensions as follows: modification 1: a = 13.64 A, b = 32.16 A, c = 14.93 A, beta = 114.8 degrees and modification 2: a = 13.79 A, b = 31.94 A, c = 15.66 A, beta = 117.5 degrees. Each structure has been solved to atomic resolution and refined by Fourier and least squares methods; the first has been refined to a residual of 0.187 on 1,903 reflections, while the second has been refined to a residual of 0.187 on 1,001 reflections. The asymmetric unit in both structures contains two ethidium molecules and two CpG molecules; the first structure has 30 water molecules (a total of 158 non-hydrogen atoms), while the second structure has 19 water molecules (a total of 147 non-hydrogen atoms). Both structures demonstrate intercalation of ethidium between base-paired CpG dimers. In addition, ethidium molecules stack on either side of the intercalated duplex, being related by a unit cell translation along the a axis. The basic feature of the sugar-phosphate chains accompanying ethidium intercalation in both structures is: C3' endo (3'-5') C2' endo. This mi...Continue Reading

References

Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·H M SobellT D Sakore

❮ Previous
Next ❯

Citations

Feb 6, 2009·Journal of the American Chemical Society·Costin M GhergheKevin M Weeks
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·V K Misra, B Honig
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·J E CouryL A Bottomley
Feb 1, 1995·Journal of Biomolecular Structure & Dynamics·G ColmenarejoG Orellana
Oct 1, 1995·Journal of Biomolecular Structure & Dynamics·R G Barr
Aug 5, 2000·Journal of Molecular Biology·C BaughC Wilson
Jul 18, 2000·Biopolymers·C MedhiA B Tabor
Mar 18, 2016·Journal of Structural and Functional Genomics·Henry M Sobell
Nov 3, 2006·Biopolymers·Micah J McCauley, Mark C Williams
Oct 26, 2005·Physical Review Letters·Ioana D VladescuMark C Williams
Jan 1, 2015·Beilstein Journal of Organic Chemistry·Lidija-Marija TumirIvo Piantanida
Mar 25, 2009·Journal of the American Chemical Society·Eric D HorowitzNicholas V Hud
Apr 18, 2021·Physical Review. E·Abhishek AggarwalPrabal K Maiti
May 28, 2021·RSC Chemical Biology·Amirrasoul TavakoliJung-Hyun Min
Oct 5, 1986·Journal of Molecular Biology·T P LybrandP A Kollman
Jul 3, 2018·ACS Combinatorial Science·Hafeez S HaniffMatthew D Disney
Sep 18, 2020·The Journal of Physical Chemistry. B·Joseph TibbsJustin P Peters

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.