Visualization of drug target interactions in the contexts of pathways and networks with ReactomeFIViz

F1000Research
Aurora S BlucherGuanming Wu

Abstract

The precision medicine paradigm is centered on therapies targeted to particular molecular entities that will elicit an anticipated and controlled therapeutic response. However, genetic alterations in the drug targets themselves or in genes whose products interact with the targets can affect how well a drug actually works for an individual patient. To better understand the effects of targeted therapies in patients, we need software tools capable of simultaneously visualizing patient-specific variations and drug targets in their biological context. This context can be provided using pathways, which are process-oriented representations of biological reactions, or biological networks, which represent pathway-spanning interactions among genes, proteins, and other biological entities. To address this need, we have recently enhanced the Reactome Cytoscape app, ReactomeFIViz, to assist researchers in visualizing and modeling drug and target interactions. ReactomeFIViz integrates drug-target interaction information with high quality manually curated pathways and a genome-wide human functional interaction network. Both the pathways and the functional interaction network are provided by Reactome, the most comprehensive open source biologi...Continue Reading

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Software Mentioned

Mechismo
CytoscapePlugIn
PARADIGM
ReactomeFIVIz
Panther
Eclipse
ChEMBL
Excel
KEGG
ConsensusPathDB

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