PMID: 7539284Apr 1, 1995Paper

Visualization of INT2 and HST1 amplification in oral squamous cell carcinomas

Genes, Chromosomes & Cancer
C M LeseSusanne M Gollin

Abstract

Oral squamous cell carcinoma (OSCC) develops along a multistep genetic pathway including loss of tumor suppressor genes and alteration of oncogenes. We characterized seven OSCC cell lines by classical and molecular cytogenetic analysis and fresh tumor and adjacent oral mucosa corresponding to three of the cell lines by molecular cytogenetics. We observed homogeneously staining regions (hsrs) in four of the seven cell lines, at 11q13 in three and at 11q23 and in an unidentified marker chromosome in the fourth. Amplification of band 11q13 occurs in 30-60% of head and neck squamous cell carcinomas. To determine whether INT2 and HST1, both located in band 11q13, are amplified in the tissues and cell lines and to confirm the chromosomal location(s) of the amplification, we used dual-color fluorescence in situ hybridization (FISH) with DNA probes for these genes and the chromosome 11 centromere. We report chromosomal localization of INT2/HST1 amplification in OSCC. Coamplification of INT2 and HST1 was detected in the hsrs in cultured tumor cells from the four hsr-containing tumors and in directly harvested tumor cells, which were available from only two of these tumors. Amplification was not present in tumors lacking hsrs or adjacent...Continue Reading

References

May 1, 1992·Mutation Research·P GaudrayC Theillet
Sep 20, 1991·Cell·T Hunter, J Pines
Nov 22, 1991·Science·E SolomonA D Goddard
Jun 19, 1991·International Journal of Cancer. Journal International Du Cancer·J H LeonardN K Hayward
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Jan 1, 1986·Cancer Investigation·J Fogh
Mar 1, 1994·Genes, Chromosomes & Cancer·D L Van DykeT E Carey
Jun 1, 1993·Genes, Chromosomes & Cancer·H RoelofsM Giphart-Gassler
Nov 1, 1993·Archives of Otolaryngology--head & Neck Surgery·M E WilliamsP A Levine
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W JiangI B Weinstein
Jan 21, 1993·The New England Journal of Medicine·E E VokesW K Hong

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Citations

Mar 5, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Marco BlessmannAlexander Gröbe
Jan 29, 2003·The Journal of Molecular Diagnostics : JMD·Bao-Zhu YuanNicholas C Popescu
Aug 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Xin HuangTony E Godfrey
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·W S SaundersS M Gollin
Apr 15, 1999·Journal of the National Cancer Institute·J CalifanoD Sidransky
Oct 21, 2000·Molecular Pathology : MP·H K Williams
Sep 12, 2002·Expert Opinion on Therapeutic Targets·Michael JeffersHenri S Lichenstein
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Yuesheng JinFredrik Mertens
Jan 1, 1996·Progress in Histochemistry and Cytochemistry·J C Alers, H van Dekken
Apr 26, 2005·International Journal of Cancer. Journal International Du Cancer·Cathie GarnisWan L Lam
Jul 23, 2009·International Journal of Cancer. Journal International Du Cancer·Ivy F L TsuiWan L Lam
Nov 14, 2006·Genes, Chromosomes & Cancer·Shalini C ReshmiSusanne M Gollin
Jan 26, 2005·Journal of Dental Research·S C Reshmi, S M Gollin
May 10, 2001·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·L Lo Muzio
Apr 29, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S Kiuru-KuhlefeltS Knuutila
Jan 31, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ilda Patrícia RibeiroIsabel Marques Carreira
Mar 9, 1999·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·K YamamotoM Sugimura

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